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PTGC may be associated with numerous systemic medical conditions that require further workup and management, including malignancy, autoimmune conditions, lymphoproliferative conditions, immunodeficiency, and infection. Given the breadth and rarity of the associated conditions, workup should be tailored to the individual patient and occur in a tiered approach. Patients with PTGC require ongoing follow\u2010up, given their long\u2010term risk of malignancy and recurrent PTGC.<\/jats:p>","DOI":"10.1002\/pbc.29638","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T11:28:24Z","timestamp":1647430104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["How I approach: The workup and management of patients with progressive transformation of the germinal center"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8300-3095","authenticated-orcid":false,"given":"Adam Paul","family":"Yan","sequence":"first","affiliation":[{"name":"Division of Haematology\/Oncology Hospital for Sick Children (SickKids)  Toronto Ontario Canada"},{"name":"Division of Hematology &amp; Oncology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatric Oncology Dana Farber Cancer Institute  Boston 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