{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:04:39Z","timestamp":1753869879796,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T00:00:00Z","timestamp":1648252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with therapy\u2010refractory or high\u2010risk relapsed classical Hodgkin lymphoma are typically treated with the high\u2010dose chemotherapy and autologous stem cell transplantation (HDC\/ASCT) to consolidate the response to salvage therapy. The combination of brentuximab vedotin with gemcitabine has recently been shown to be an effective and safe salvage regimen. While the majority of patients with complete responses to this regimen ultimately underwent HDC\/ASCT consolidation, four subjects, reported herein, achieved durable complete remissions lasting more than 4\u00a0years after the study treatment but without ASCT consolidation. Further investigation of treatment strategies incorporating targeted agents may allow omission of HDC\/ASCT for select patients.<\/jats:p>","DOI":"10.1002\/pbc.29649","type":"journal-article","created":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T10:48:16Z","timestamp":1648291696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Durable remission for four pediatric patients with high\u2010risk relapsed classical Hodgkin lymphoma treated with brentuximab vedotin plus gemcitabine but without autologous stem cell transplantation: A report from the Children's Oncology Group"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5207-4616","authenticated-orcid":false,"given":"Ilia N.","family":"Buhtoiarov","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation Cleveland Clinic Children's  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nkechi I.","family":"Mba","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Driscoll Children's Hospital  Corpus Christi Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crystal D. 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