{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:58:27Z","timestamp":1765357107639,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mRNA COVID\u201019 vaccine and COVID\u201019 infection caused by the SARS\u2010CoV\u20102 virus may be immunologic triggers for the development of thrombotic thrombocytopenic purpura (TTP). There is not yet literature that discusses TTP induced by COVID\u201019 vaccination or infection in pediatric or adolescent patients. We describe three adolescents presenting with TTP (both de novo and relapsed disease) following administration of the Pfizer COVID\u201019 vaccine or after COVID\u201019 infection. Our observations demonstrate that the Pfizer\u2010BioNTech mRNA vaccine and COVID\u201019 infection can act as triggers for the development\/relapse of both congenital and acquired TTP.<\/jats:p>","DOI":"10.1002\/pbc.29681","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T12:05:02Z","timestamp":1649073902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["COVID\u201019 vaccine (mRNA BNT162b2) and COVID\u201019 infection\u2010induced thrombotic thrombocytopenic purpura in adolescents"],"prefix":"10.1002","volume":"69","author":[{"given":"Luna","family":"Vorster","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine Texas Children's Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Kirk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\/Oncology, Baylor College of Medicine Texas Children's Hospital  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Muscal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Rheumatology, Baylor College of Medicine Texas Children's Hospital  Houston TX USA"},{"name":"Department of Pediatrics, Section of Neurology\/Developmental Neuroscience, Baylor College of Medicine Texas Children's Hospital  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9569-3636","authenticated-orcid":false,"given":"Jenny M.","family":"Despotovic","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\/Oncology, Baylor College of Medicine Texas Children's Hospital  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6819-4049","authenticated-orcid":false,"given":"Clay T.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\/Oncology, Baylor College of Medicine Texas Children's Hospital  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2204-4568","authenticated-orcid":false,"given":"Sarah E.","family":"Sartain","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\/Oncology, Baylor College of Medicine Texas Children's Hospital  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23527"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182755c38"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15418"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2021.103145"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.05.054"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2021.102663"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26132"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17645"},{"issue":"11","key":"e_1_2_6_10_1","first-page":"996","article-title":"Immune thrombocytopenic purpura after vaccination with COVID\u201019 vaccine (ChAdOx1 nCov\u201019)","volume":"138","author":"Paulsen FO","year":"2021","journal-title":"Blood"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-021-03190-y"},{"issue":"7","key":"e_1_2_6_12_1","article-title":"A case of COVID\u201019 induced thrombotic thrombocytopenic purpura","volume":"13","author":"Shankar K","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.2957"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000776"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2020.04.062"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22091"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.002493"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13524"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26007"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2021.108665"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102524"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108480"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011548"},{"key":"e_1_2_6_24_1","unstructured":"VAERS US. 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