{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:42:10Z","timestamp":1793284930439,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine if proton therapy reduces doses to cranial organs at risk (OARs) as compared to photon therapy in children with non\u2010germinomatous germ cell tumors (NGGCT) receiving whole ventricular radiotherapy (WVRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>Dosimetric data for patients with NGGCT prospectively enrolled in stratum 1 of the Children's Oncology Group study ACNS1123 who received 30.6\u00a0Gy WVRT were compared. Target segmentation was standardized using a contouring atlas. Doses to cranial OARs were compared between proton and photon treatments. Clinically relevant dose\u2010volume parameters that were analyzed included mean dose and dose to 40% of the OAR volume (D40).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean and D40 doses to the supratentorial brain, cerebellum, and bilateral temporal, parietal, and frontal lobes were statistically significantly lower amongst proton\u2010treated patients, as compared to photon\u2010treated patients. In a subgroup analysis of patients uniformly treated with a 3\u2010mm planning target volume, patients who received proton therapy continued to have statistically significantly lower doses to brain OARs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children treated with proton therapy for WVRT had lower doses to normal brain structures, when compared to those treated with photon therapy. Proton therapy should be considered for patients receiving WVRT for NGGCT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29697","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T12:19:01Z","timestamp":1649074741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Photon versus proton whole ventricular radiotherapy for non\u2010germinomatous germ cell tumors: A report from the Children's Oncology Group"],"prefix":"10.1002","volume":"69","author":[{"given":"David Y.","family":"Mak","sequence":"first","affiliation":[{"name":"Radiation Medicine Program, Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zain","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Cancer Center of Southeastern Ontario  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui Amy","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitesh","family":"Dama","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program, Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon M.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin S.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cleveland Clinic Taussig Cancer Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Miami Cancer Institute Baptist Health South Florida  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Malkov","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program, Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Onar\u2010Thomas","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameera","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program, Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Dhall","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Blood &amp; 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