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Nuclear medicine imaging modalities such as fluorodeoxyglucose positron emission tomography (<jats:sup>18<\/jats:sup>F\u2010FDG PET), <jats:sup>68<\/jats:sup>Ga\u2010DOTATATE PET, and <jats:sup>123<\/jats:sup>I\u2010metaiodobenzylguanidine (<jats:sup>123<\/jats:sup>I\u2010MIBG) scintigraphy play an essential role in the staging, response assessment, and determination of suitability for targeted radiotherapy in patients with PPGL. Each of these functional imaging modalities targets a different cellular characteristic and as such can be complementary to anatomic imaging and to each other. With the recent US Food and Drug Administration approval and increasing use of <jats:sup>68<\/jats:sup>Ga\u2010DOTATATE for imaging in children, the purpose of this article is to use a case\u2010based approach to highlight both the advantages and limitations of DOTATATE imaging as it is compared to current radiologic imaging techniques in the staging and response assessment of pediatric PPGL, as well as other neuroendocrine malignancies.<\/jats:p>","DOI":"10.1002\/pbc.29740","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T08:02:30Z","timestamp":1651219350000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<sup>68<\/sup>Ga\u2010DOTATATE PET and functional imaging in pediatric pheochromocytoma and paraganglioma"],"prefix":"10.1002","volume":"69","author":[{"given":"Aleksandra A.","family":"Krokhmal","sequence":"first","affiliation":[{"name":"Department of Radiology Mount Auburn Hospital  Cambridge USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Kwatra","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Children's Hospital  Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Drubach","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Children's Hospital  Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4610-9784","authenticated-orcid":false,"given":"Christopher B.","family":"Weldon","sequence":"additional","affiliation":[{"name":"Department of Surgery Boston Children's Hospital  Boston USA"},{"name":"Dana\u2010Farber\/Boston Children's Cancer and Blood Disorders Center  Boston USA"},{"name":"Department of Anesthesiology Critical Care &amp; Pain Medicine. 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