{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T21:43:14Z","timestamp":1764020594032,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The MLL\u201010 trial (UMIN000004801) modified a Children's Oncology Group (COG) AALL0631 therapy for infants with <jats:italic>KMT2A<\/jats:italic>\u2010rearranged acute lymphoblastic leukemia (ALL). In 2016, one registered case developed secondary immunodeficiency during maintenance therapy and eventually died due to cytomegalovirus infection. Around the same time, fatal secondary immunodeficiencies were reported in five infants with ALL in North America who had received COG\u2010based chemotherapy between 1996 and 2015. Given these cases, we decided to conduct a retrospective study on the postchemotherapy immune status of infants with ALL. A questionnaire collected data on posttreatment immune function, frequency of infections, and supportive care for the 34 infants in the MLL\u201010 trial. Patients receiving allogeneic hematopoietic stem cell transplantation in first remission were excluded. Responses to the survey were obtained in 28 cases (85%). Most patients were immunocompetent after the completion of chemotherapy (median follow\u2010up duration from the day of chemotherapy completion was 431\u00a0days), except for the aforementioned case. There were seven patients with nonsevere viral infection, all of whom recovered. In conclusion, severe chemotherapy\u2010induced immunodeficiency in infants with ALL appears to be rare, but prospective data collection of immune function is necessary to clarify this finding.<\/jats:p>","DOI":"10.1002\/pbc.29772","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T11:16:26Z","timestamp":1657192586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Postchemotherapy immune status in infants with acute lymphoblastic leukemia: A report from the JPLSG MLL\u201010 trial"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3001-2240","authenticated-orcid":false,"given":"Yuki","family":"Arakawa","sequence":"first","affiliation":[{"name":"Department of Haematology and Oncology Saitama Children's Medical Center  Saitama 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