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By analyzing changes in tumor extent, serum tumor markers, and pathologies between diagnosis and transfer, those events could be attributed to postbiopsy respiratory insufficiency, growing teratoma syndrome, secondary histiocytic malignancy, and PMNSGCT progression. Subjecting patients to respiratory therapy, conventional or high\u2010dose chemotherapy, and surgery controlled the disease, with five of the eight patients surviving disease free. These outcomes indicate that integrated appropriate and timely approaches are important in tackling peri\u2010treatment adverse events.<\/jats:p>","DOI":"10.1002\/pbc.29781","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T07:34:58Z","timestamp":1653032098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peri\u2010treatment adverse events of primary mediastinal non\u2010seminomatous germ cell tumors"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-9886","authenticated-orcid":false,"given":"Rong\u2010Long","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Koo Foundation Sun Yat\u2010Sen Cancer Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Chuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Koo Foundation Sun Yat\u2010Sen Cancer Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng Peng","family":"Ip","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology Academia Sinica  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Hua","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Koo Foundation Sun Yat\u2010Sen Cancer Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Sun","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Pathology Koo Foundation Sun Yat\u2010Sen Cancer Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9857-068X","authenticated-orcid":false,"given":"Liuh\u2010Yow","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology Academia Sinica  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32835f085d"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.5337"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2019.04.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25895"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.69.8910"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_201139"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.10.2638"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067749"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.7.1390"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.05.053"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759\u20107714.13231"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11068"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.12.082"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds579"},{"issue":"1","key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.33590\/emjoncol\/10310463","article-title":"Chemotherapy for extracranial germ cell tumours in paediatric, adolescent, and young adult patients","volume":"5","author":"Chen RL","year":"2017","journal-title":"EMJ Oncol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.1561"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.07.178"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002515"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.03.013"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.optechstcvs.2009.02.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759\u20107714.13859"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.1.54"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005173222004"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010003\u20100787\u2010x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705991"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1311"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029\u2010012\u20109433\u2010y"}],"container-title":["Pediatric Blood &amp; 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