{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T22:31:50Z","timestamp":1792362710641,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In 2018, the World Health Organization (WHO) launched the Global Initiative for Childhood Cancer (GICC). The goal is to achieve a global survival rate of at least 60% for all children with cancer by 2030. Morocco was designated as a pilot country for this initiative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>This retrospective study included a cohort of children aged 0\u201315\u00a0years, with one of the six indexed cancers (acute lymphoblastic leukemia [ALL], Burkitt lymphoma [BL], Hodgkin lymphoma, retinoblastoma [RB], Wilms tumor or nephroblastoma, low\u2010grade glioma), diagnosed between January 1, 2017 and December 31, 2019 at the six Moroccan Pediatric Hematology and Oncology units. Patients were followed\u2010up until August 31, 2020. The Kaplan\u2013Meier method was used to estimate survival rates, the log\u2010rank test for comparing survival curves, and the Cox model for identifying prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data on 878 patients were included in the study. The most frequently reported cancer type was ALL (<jats:italic>n<\/jats:italic>\u00a0=\u00a0383, 43.6%), followed by Wilms tumor (<jats:italic>n<\/jats:italic>\u00a0=\u00a0139, 15.8%) and BL (<jats:italic>n<\/jats:italic>\u00a0=\u00a0133, 15%). Most patients were less than 5\u00a0years of age (<jats:italic>n<\/jats:italic>\u00a0=\u00a0446, 50.9%) and the male\/female ratio was 1.46. The 1, 2, and 3\u2010year overall survival rates were 80.1%, 73.6%, and 68.2%, respectively. In a multivariable Cox regression model, care center, cancer type, age group, and distance to the care center were statistically significantly associated to survival. Patients aged 10\u00a0years and older and patients living more than 100\u00a0km from the care center were more likely to die (respectively, HR\u00a0=\u00a01.39, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.045 and HR\u00a0=\u00a01.44, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The reported results represent the baseline for measuring the impact of GICC implementation in Morocco.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29788","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T11:07:26Z","timestamp":1657192046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Implementing the WHO Global Initiative for Childhood Cancer in Morocco: Survival study for the six indexed childhood cancers"],"prefix":"10.1002","volume":"69","author":[{"given":"Nada Bennani","family":"Mechita","sequence":"first","affiliation":[{"name":"Directorate of Epidemiology and Disease Control  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siham","family":"Cherkaoui","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Unit 2O August Hospital Casablanca, Moroccan Society of Pediatric Hematology and Oncology  Casablanca Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loubna","family":"Abousselham","sequence":"additional","affiliation":[{"name":"Directorate of Epidemiology and Disease Control  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarra","family":"Benmiloud","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Unit of F\u00e8s Moroccan Society of Pediatric Hematology and Oncology  F\u00e8s Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Kili","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Department of Rabat Moroccan Society of Pediatric Hematology and Oncology  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria El","family":"Kababri","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Department of Rabat Moroccan Society of Pediatric Hematology and Oncology  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Maani","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Unit at Abderrahim El Harouchi Hospital Casablanca Moroccan Society of Pediatric Hematology and Oncology  Casablanca Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamila El","family":"Houdzi","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Department of Marrakech Moroccan Society of Pediatric Hematology and Oncology  Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noufissa","family":"Benajiba","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Department of Oujda Moroccan Society of Pediatric Hematology and Oncology  Oujda Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdellah","family":"Madani","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Unit 2O August Hospital Casablanca, Moroccan Society of Pediatric Hematology and Oncology  Casablanca Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bennani","sequence":"additional","affiliation":[{"name":"Lalla Salma Foundation \u2010 Cancer Prevention and Treatment  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latefa","family":"Belakhel","sequence":"additional","affiliation":[{"name":"Directorate of Epidemiology and Disease Control  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bouffet","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Patte","sequence":"additional","affiliation":[{"name":"Francophone African Group of Pediatric Oncology, Gustave Roussy Institut  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mhamed","family":"Harif","sequence":"additional","affiliation":[{"name":"University Hospital Center of Tangier  Tangier Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Youbi","sequence":"additional","affiliation":[{"name":"Directorate of Epidemiology and Disease Control  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Hessissen","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Department of Rabat Moroccan Society of Pediatric Hematology and Oncology  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30186-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1596\/978-1-4648-0349-9_ch7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw4892"},{"key":"e_1_2_8_5_1","volume-title":"WHO Global Initiative for Childhood Cancer: an 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