{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:28:14Z","timestamp":1771061294589,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brentuximab vedotin (BV) is an antibody drug\u2010conjugated anti\u2010CD30 approved for the treatment of adult classical Hodgkin's lymphoma (HL), whereas it is considered as off\u2010label indication in paediatrics. The aim of the study was to evaluate the safety and efficacy of BV to treat patients aged less than 18\u00a0years with refractory\/relapsed HL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In this multicentre, retrospective study, 68 paediatric patients who received at least one dose of BV between November 2011 and August 2020 were enrolled. A median of nine doses of BV were administered as monotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a031) or combined with other therapies (<jats:italic>n<\/jats:italic>\u00a0=\u00a037). BV was administrated alone as consolidation therapy after stem cell transplantation (SCT) in 12 patients, before SCT in 18 patients, whereas in 15 patients it was used before and after SCT as consolidation therapy. Median follow\u2010up was 2.8\u00a0years (range: 0.6\u20138.9\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The best response was observed in the 86% of patients; the overall response rate was 66%. The 3\u2010year progression\u2010free survival was 58%, whereas the overall survival was 75%. No statistically significant differences between patients treated with BV monotherapy or combination were highlighted. In multivariate analysis, patients with non\u2010nodular sclerosis HL and not transplanted had an increased risk of failure. Overall, 46% of patients had grade 3\u20134 adverse events that led to BV discontinuation in five of them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, our study confirms that BV was a safe and effective drug, able to induce complete remission, either as monotherapy or in association with standard therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29801","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T09:16:28Z","timestamp":1654247788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Brentuximab vedotin in the treatment of paediatric patients with relapsed or refractory Hodgkin's lymphoma: Results of a real\u2010life study"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1226-5116","authenticated-orcid":false,"given":"Davide","family":"Massano","sequence":"first","affiliation":[{"name":"Paediatric Hematology, Oncology and Stem Cell Transplant Division Padova University Hospital  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6675-867X","authenticated-orcid":false,"given":"Elisa","family":"Carraro","sequence":"additional","affiliation":[{"name":"Paediatric Hematology, Oncology and Stem Cell Transplant Division Padova University Hospital  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4802-1866","authenticated-orcid":false,"given":"Lara","family":"Mussolin","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Department Padova University Hospital  Padua Italy"},{"name":"Istituto di Ricerca Pediatrica Citt\u00e0 della Speranza  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Buffardi","sequence":"additional","affiliation":[{"name":"Paediatric Haemato\u2010Oncology Department Santobono\u2010Pausilipon Children's Hospital  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Barat","sequence":"additional","affiliation":[{"name":"Paediatric Onco\u2010Hematology and Stem Cell Transplant Division, City of Health and Science Regina Margherita Children's Hospital  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Zama","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Sant'Orsola Hospital University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Muggeo","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology and Hematology University Hospital of Policlinico  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1818-2757","authenticated-orcid":false,"given":"Francesca","family":"Vendemini","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Ospedale San Gerardo University of Milano\u2010Bicocca, Fondazione MBBM  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Sau","sequence":"additional","affiliation":[{"name":"Paediatric Hematology\u2010Oncology Unit Ospedale Civico  Pescara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2138-4894","authenticated-orcid":false,"given":"Maria Luisa","family":"Moleti","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine \u2018Sapienza\u2019 University  Rome 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