{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T03:25:28Z","timestamp":1774668328773,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Approximately 25% of B\u2010cell acute lymphoblastic leukemia (B\u2010ALL) cases are defined by hyperdiploidy, with <jats:italic>RAS<\/jats:italic> mutations occurring in 30% of hyperdiploid B\u2010ALL patients. It is believed that hyperdiploidy is an in utero event with <jats:italic>RAS<\/jats:italic> mutations occurring postnatally, but clinical evidence of this is based on relatively few patients. We present a case of monozygotic, monochorionic twins who developed concordant hyperdiploid B\u2010ALL with identical chromosomal gains but different <jats:italic>RAS<\/jats:italic> mutations, adding further evidence that hyperdiploidy is occurring prenatally, with <jats:italic>RAS<\/jats:italic> mutations developing postnatally. Environmental exposures were reviewed with the family without identification of a clear association.<\/jats:p>","DOI":"10.1002\/pbc.29885","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T12:47:50Z","timestamp":1658321270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The two\u2010hit hypothesis in practice: Monozygotic twins with simultaneous hyperdiploid acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"69","author":[{"given":"Kimberly","family":"Davidow","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Nemours Center for Cancer and Blood Disorders Nemours Children's Hospital \u2010 Delaware  Wilmington Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mumanachit","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Nemours Children's Hospital \u2010 Delaware  Wilmington Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Spencer","family":"Mangum","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Nemours Center for Cancer and Blood Disorders Nemours Children's Hospital \u2010 Delaware  Wilmington Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1400972"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.639479"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102002\u201001\u20100144"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.152"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.1.203.203"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20222"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2010.07.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102002\u201012\u20103817"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.177"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20502"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2799"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.303"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.1230.13.7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.21.1626"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1081\/CNV\u201046402"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2012.689555"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.29885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.29885","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.29885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T11:36:02Z","timestamp":1692790562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.29885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,20]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/pbc.29885"],"URL":"https:\/\/doi.org\/10.1002\/pbc.29885","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,20]]},"assertion":[{"value":"2022-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e29885"}}