{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:58:21Z","timestamp":1787752701347,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neutropenia related to <jats:italic>ELANE<\/jats:italic> gene mutations predisposes patients to infection and leukemia\/myelodysplasia, but little is known about the predisposition to cancer. Among a cohort of 147 patients, we identified four with malignant solid tumors (papillary thyroid cancer, anal squamous cell cancer, papillary renal cell carcinoma, and adrenocortical carcinoma), all aged 25\u201350 years. Three occurred with cyclic neutropenia, and one occurred with severe chronic neutropenia. Previous radiotherapy was identified as a risk factor in one patient. No genetic predisposition was identified in the three other patients.<\/jats:p>","DOI":"10.1002\/pbc.29923","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T13:38:47Z","timestamp":1660570727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>ELANE<\/i> neutropenia and solid tumors: Four cases from the French severe chronic neutropenia registry"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4485-146X","authenticated-orcid":false,"given":"Jean","family":"Donadieu","sequence":"first","affiliation":[{"name":"French Registry for Severe Chronic Neutropenia Armand\u2010Trousseau Hospital APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2773-048X","authenticated-orcid":false,"given":"Fares","family":"Bou Mitri","sequence":"additional","affiliation":[{"name":"French Registry for Severe Chronic Neutropenia Armand\u2010Trousseau Hospital APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Beaupain","sequence":"additional","affiliation":[{"name":"French Registry for Severe Chronic Neutropenia Armand\u2010Trousseau Hospital APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0231-4460","authenticated-orcid":false,"given":"Nathalie","family":"Alajidi","sequence":"additional","affiliation":[{"name":"Onco\u2010hematology Unit Pediatic Department Children Hospital Groupe Hospitalier Pellegrin  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Francois","family":"Viallard","sequence":"additional","affiliation":[{"name":"Internal Medicine and Infectious Disease Department Haut\u2010L\u00e9v\u00eaque Hospital University of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe Le","family":"Paih","sequence":"additional","affiliation":[{"name":"Urology Department Bordeaux University Hospital  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mokrane","family":"Yacoub","sequence":"additional","affiliation":[{"name":"Pathology Department Bordeaux University Hospital  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Leblanc","sequence":"additional","affiliation":[{"name":"Hematology Unit Robert Debr\u00e9 Hospital APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Quero","sequence":"additional","affiliation":[{"name":"Oncology and Radiotherapy Department Hopital Saint Louis APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Rouland","sequence":"additional","affiliation":[{"name":"Endocrinology Department Dijon University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Labbe","sequence":"additional","affiliation":[{"name":"Endocrinology Department Hotel Dieu  Le Creusot France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Deback","sequence":"additional","affiliation":[{"name":"Virology Department Paul Brousse Hospital  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Bellanne\u2010Chantelot","sequence":"additional","affiliation":[{"name":"Genetics Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Emile","sequence":"additional","affiliation":[{"name":"Pathology Department Ambroise\u2010Par\u00e9 Hospital APHP  Boulogne France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.7.2317"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/70544"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17695"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-0800-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22308"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000105"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005684"},{"key":"e_1_2_8_9_1","first-page":"45","article-title":"Analysis of risk factors for myelodysplasias, leukemias and death from infection among patients with congenital neutropenia. 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