{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:28:15Z","timestamp":1788197295578,"version":"build-2803163510"},"reference-count":74,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>T\u2010cell lymphoblastic lymphoma (T\u2010LBL) is an aggressive neoplasm closely related to T\u2010cell acute lymphoblastic leukaemia (T\u2010ALL). Despite their similarities, and contrary to T\u2010ALL, studies on paediatric T\u2010LBL are scarce and, therefore, its molecular landscape has not yet been fully elucidated. Thus, the aims of this study were to characterize the genetic and molecular heterogeneity of paediatric T\u2010LBL and to evaluate novel molecular markers differentiating this entity from T\u2010ALL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>Thirty\u2010three paediatric T\u2010LBL patients were analyzed using an integrated approach, including targeted next\u2010generation sequencing, RNA\u2010sequencing transcriptome analysis and copy\u2010number arrays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Copy number and mutational analyses allowed the detection of recurrent homozygous deletions of 9p\/\n                      <jats:italic>CDKN2A<\/jats:italic>\n                      (78%), trisomy 20 (19%) and gains of 17q24\u2010q25 (16%), as well as frequent mutations of\n                      <jats:italic>NOTCH1<\/jats:italic>\n                      (62%), followed by the\n                      <jats:italic>BCL11B<\/jats:italic>\n                      (23%),\n                      <jats:italic>WT1<\/jats:italic>\n                      (19%) and\n                      <jats:italic>FBXW7<\/jats:italic>\n                      ,\n                      <jats:italic>PHF6<\/jats:italic>\n                      and\n                      <jats:italic>RPL10<\/jats:italic>\n                      genes (15%, respectively). This genetic profile did not differ from that described in T\u2010ALL in terms of mutation incidence and global genomic complexity level, but unveiled virtually exclusive 17q25 gains and trisomy 20 in T\u2010LBL. Additionally, we identified novel gene fusions in paediatric T\u2010LBL, including\n                      <jats:italic>NOTCH1\u2013IKZF2<\/jats:italic>\n                      ,\n                      <jats:italic>RNGTT\u2013SNAP91<\/jats:italic>\n                      and\n                      <jats:italic>DDX3X\u2013MLLT10<\/jats:italic>\n                      , the last being the only one previously described in T\u2010ALL. Moreover, clinical correlations highlighted the presence of Notch pathway alterations as a factor related to favourable outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In summary, the genomic landscape of paediatric T\u2010LBL is similar to that observed in T\u2010ALL, and Notch signaling pathway deregulation remains the cornerstone in its pathogenesis, including not only mutations but fusion genes targeting\n                      <jats:italic>NOTCH1<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.29926","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T09:23:51Z","timestamp":1661333031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Diverse mutations and structural variations contribute to Notch signaling deregulation in paediatric T\u2010cell lymphoblastic lymphoma"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7092-9160","authenticated-orcid":false,"given":"Julia","family":"Salmer\u00f3n\u2010Villalobos","sequence":"first","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Oncolog\u00eda (CIBERONC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7108-7738","authenticated-orcid":false,"given":"Joan Enric","family":"Ramis\u2010Zaldivar","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Oncolog\u00eda (CIBERONC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5099-3675","authenticated-orcid":false,"given":"Olga","family":"Balagu\u00e9","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Oncolog\u00eda (CIBERONC)  Madrid Spain"},{"name":"Haematopathology Unit Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0900-0889","authenticated-orcid":false,"given":"Jaime","family":"Verd\u00fa\u2010Amor\u00f3s","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Department Hospital Cl\u00ednic  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Celis","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Department Hospital Sant Joan de D\u00e9u  Esplugues de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3956-5466","authenticated-orcid":false,"given":"Constantino","family":"S\u00e1bado","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Department Hospital Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garrido","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Department Hospital Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7269-2470","authenticated-orcid":false,"given":"Sara","family":"Mato","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Oncolog\u00eda (CIBERONC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Uriz","sequence":"additional","affiliation":[{"name":"Paediatric Oncohaematology Department Donostia University Hospital Biodonostia Health Research Institute  San Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Jos\u00e9","family":"Ortega","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Department Hospital Universitario Virgen de la Nieves  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8679-6868","authenticated-orcid":false,"given":"Angela","family":"Gutierrez\u2010Camino","sequence":"additional","affiliation":[{"name":"Division of Haematology\u2010Oncology CHU Sainte\u2010Justine Research Center  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3625-6676","authenticated-orcid":false,"given":"Daniel","family":"Sinnett","sequence":"additional","affiliation":[{"name":"Division of Haematology\u2010Oncology CHU Sainte\u2010Justine Research Center  Montreal Canada"},{"name":"Department of Paediatrics Faculty of Medicine University of Montreal  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7418-5616","authenticated-orcid":false,"given":"Unai","family":"Illarregi","sequence":"additional","affiliation":[{"name":"Genetics, Physics Anthropology and Animal Physiology Faculty of Science and Technology UPV\/EHU  Leioa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3733-5723","authenticated-orcid":false,"given":"M\u00e1xime","family":"Carron","sequence":"additional","affiliation":[{"name":"Division of Haematology\u2010Oncology CHU Sainte\u2010Justine Research Center  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3156-4784","authenticated-orcid":false,"given":"Alexandra","family":"Regueiro","sequence":"additional","affiliation":[{"name":"Paediatric Haematology and Oncology Department Hospital Cl\u00ednico Universitario de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-8003","authenticated-orcid":false,"given":"Ana","family":"Galera","sequence":"additional","affiliation":[{"name":"Paediatric Oncohaematology Department Hospital Cl\u00ednico Universitario Virgen de la Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1796-7248","authenticated-orcid":false,"given":"Blanca","family":"Gonzalez\u2010Farr\u00e9","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Oncolog\u00eda (CIBERONC)  Madrid Spain"},{"name":"Haematopathology Unit Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9850-9793","authenticated-orcid":false,"given":"Elias","family":"Campo","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Oncolog\u00eda (CIBERONC)  Madrid Spain"},{"name":"Haematopathology Unit Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Garcia","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7486-8484","authenticated-orcid":false,"given":"Dolors","family":"Colomer","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Oncolog\u00eda (CIBERONC)  Madrid Spain"},{"name":"Haematopathology Unit Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5012-0137","authenticated-orcid":false,"given":"Itziar","family":"Astigarraga","sequence":"additional","affiliation":[{"name":"Paediatric Department Osakidetza Biocruces Bizkaia Health Research Institute Hospital Universitario Cruces  Barakaldo Spain"},{"name":"Paediatric Department Universidad del Pais Vasco UPV\/EHU  Leioa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8274-5724","authenticated-orcid":false,"given":"Mara","family":"Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Department Hospital La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Llavador","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Department Hospital La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-1908","authenticated-orcid":false,"given":"Idoia","family":"Martin\u2010Guerrero","sequence":"additional","affiliation":[{"name":"Biocruces Bizkaia Health Research Institute Department of Genetics, Physical Anthropology &amp; Animal Physiology, Science and Technology Faculty University of the Basque Country UPV\/EHU  Leioa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2427-9822","authenticated-orcid":false,"given":"Itziar","family":"Salaverria","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red\u2010Oncolog\u00eda (CIBERONC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"SEER*Explorer: an interactive website for SEER cancer statistics [Internet]. Surveillance Research Program.National Cancer Institute. Accessed September 27 2021.https:\/\/seer.cancer.gov\/explorer\/"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05735.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001822"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20924"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2009.01.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005381"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-020-0310-9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-474148"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80613-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13105"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3909"},{"issue":"2","key":"e_1_2_10_13_1","first-page":"416","article-title":"Intensive ALL\u2010type therapy without local radiotherapy provides a 90% event\u2010free survival for children with T\u2010cell lymphoblastic lymphoma: a BFM group report","volume":"95","author":"Reiter A","year":"2000","journal-title":"Blood"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.139162"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.3367"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.7661"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07607.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404275"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701824551"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.203"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00018-1"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404302"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-005-0050-7"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2006.07.011"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08788.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41675-3"},{"key":"e_1_2_10_27_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2017"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-206722"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.251"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr407"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.86"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0410-248"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/011650"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.101725"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-487256"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-696757"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.23037"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.63"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.153"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-567636"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2012.04.006"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0016-8"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701817282"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1996"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0814-6"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-021790"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.9.759"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3911"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01901"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000015"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01239-08"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2789"},{"issue":"6","key":"e_1_2_10_55_1","first-page":"955","article-title":"Pregnancy\u2010associated plasma protein a in cancer: expression, oncogenic functions and regulation","volume":"8","author":"Guo Y","year":"2018","journal-title":"Am J Cancer Res"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100855"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4127"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3727\/000000001783992614"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2018.09.012"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-07-860726"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-687830"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.100"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21713"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08186.x"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3358"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-010-9485-4"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.12.025"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.041921"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0497-6"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092708"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900571106"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.06.003"},{"issue":"114","key":"e_1_2_10_73_1","article-title":"Wilms\u2019 tumour suppressor gene 1 (WT1) is involved in the carcinogenesis of Lung cancer through interaction with PI3K\/Akt pathway","volume":"13","author":"Wang X","year":"2013","journal-title":"Cancer Cell Int"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-08-0078"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.89"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.29926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.29926","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.29926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T06:43:35Z","timestamp":1692686615000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.29926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":74,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/pbc.29926"],"URL":"https:\/\/doi.org\/10.1002\/pbc.29926","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.165165320.05970525\/v1","asserted-by":"object"}]},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,24]]},"assertion":[{"value":"2022-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e29926"}}