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In our cohort of 46 patients, the majority had at least one course of delayed clearance and\/or creatinine elevation. Additionally, more than one\u2010third of patients experienced an episode of grade \u22653 mucositis. Creatinine elevations and delayed clearance were independently associated with subsequent grade \u22653 mucositis. We advocate for greater availability of methotrexate monitoring to allow dose escalation of this essential modality around the world.<\/jats:p>","DOI":"10.1002\/pbc.29940","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T13:49:46Z","timestamp":1662558586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety analysis of high\u2010dose methotrexate in pediatric non\u2010Hodgkin lymphomas"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9612-3624","authenticated-orcid":false,"given":"M. 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