{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:44:02Z","timestamp":1785300242085,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood & Cancer"],"published-print":{"date-parts":[[2023,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Isolated neutropenia is a common referral to pediatric hematology oncology (PHO) physicians. There are no established consensus guidelines in the diagnosis and management of patients with isolated, asymptomatic, and incidentally discovered neutropenia.<\/jats:p><\/jats:sec>Methods<\/jats:title>A survey was distributed to PHO physicians on the American Society of Pediatric Hematology Oncology member discussion page to determine the common diagnostic and management decisions regarding patients with isolated neutropenia and to explore beliefs regarding the term \u201cbenign ethnic neutropenia.\u201d<\/jats:p><\/jats:sec>Results<\/jats:title>One hundred twenty\u2010six PHO attending physicians completed the survey. The most common tests reportedly ordered for this patient population included complete blood cell count (CBC) (98%), peripheral smear (75%), antineutrophil antibody testing (29%), and immunoglobulins (24%). Providers were more likely to order an antineutrophil antibody in toddlers (p<\/jats:italic>\u00a0=\u00a0.0085), and antinuclear antibody (ANA) panels in adolescents (p<\/jats:italic>\u00a0<\u00a0.001). Half of providers do not request additional CBCs prior to their initial consultation, and most suggest referring patients with mild neutropenia after confirming a declining absolute neutrophil count (ANC) (51%). The three most important factors influencing ongoing follow\u2010up included: history of recurrent\/severe infections (98%), family history of blood disorders (98%), and more severe\/progressively worsening neutropenia (97%). Seventy percent of respondents have diagnosed patients with \u201cbenign ethnic neutropenia,\u201d and 75% support replacement of the term to \u201ctypical neutrophil count with Fy(a\u2010\/b\u2010) status,\u201d if confirmed with red cell phenotyping.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We identified practice patterns of PHO physicians for the diagnosis and management of patients referred for asymptomatic and isolated neutropenia. These data provide the framework to conduct cost\u2010effectiveness studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29946","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T13:00:25Z","timestamp":1670677225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnosis and management of isolated neutropenia: A survey of pediatric hematologist oncologists"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7886-6029","authenticated-orcid":false,"given":"Elizabeth","family":"Gunn","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology Oncology Department of Pediatrics University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquelyn M.","family":"Powers","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology Department of Pediatrics Baylor College of Medicine Texas Children's Hospital Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AKM Fazlur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Bemrich\u2010Stolz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology Department of Pediatrics University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6039-7965","authenticated-orcid":false,"given":"Stephen","family":"Mennemeyer","sequence":"additional","affiliation":[{"name":"School of Public Health University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Lebensburger","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology Department of Pediatrics University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope P.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology Department of Pediatrics University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019\u20103637"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2013.06.010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29599"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27361"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13345"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008600"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3763"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.094706"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13210"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14677"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(02)07451\u20102"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002332"}],"container-title":["Pediatric 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