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Neuroblastoma patients with OMS usually have better oncological outcomes than those without OMS even after stratification by tumor stage and age, indicating that factors mediating OMS may also inhibit tumor cell proliferation. Although the mechanisms underlying OMS remain undefined, the cytokines and lymphocytes alterations in the cerebrospinal fluid support the concept that it is a pattern of neuroinflammation due to an autoimmune effect. The presence of lymphoid follicles consisting of follicular dendritic cells, CD20\n                    <jats:sup>+<\/jats:sup>\n                    B lymphocytes, CD3\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes, and CD68\n                    <jats:sup>+<\/jats:sup>\n                    macrophages in the tumor microenvironment in OMS\u2010associated neuroblastoma support the autoimmune nature of this disorder. This review focuses on the clinical and genetic features of OMS\u2010associated neuroblastoma, and we update readers on immune features of neuroblastoma with or without OMS to gain insights into antitumor immunity as it relates to tumor biology and prognosis.\n                  <\/jats:p>","DOI":"10.1002\/pbc.29949","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T09:32:27Z","timestamp":1662975147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Opsoclonus\u2010myoclonus syndrome associated with neuroblastoma: Insights into antitumor immunity"],"prefix":"10.1002","volume":"69","author":[{"given":"Hongmei","family":"Du","sequence":"first","affiliation":[{"name":"Department of Oncology Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-1403","authenticated-orcid":false,"given":"Weisong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Oncology Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2014.10.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00374-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197102)27:2<374::AID-CNCR2820270221>3.0.CO;2-G"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.3349"},{"issue":"7","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"e924","DOI":"10.1097\/MPH.0000000000002131","article-title":"Neuroblastoma with 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