{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:56:04Z","timestamp":1787950564856,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T00:00:00Z","timestamp":1663977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Varicella\u2010zoster virus (VZV) reactivation is a serious complication of hematopoietic stem cell transplantation (HSCT). Although low\u2010dose acyclovir can prevent VZV reactivation after HSCT in adults, the efficacy of a dose of acyclovir lower than the recommended dose, such as 60\u201380\u00a0mg\/kg\/day in children, is unclear. In this study, we aimed to evaluate the incidence of VZV reactivation after HSCT during and after low\u2010dose acyclovir administration for preventing VZV reactivation in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center retrospective study included children aged \u226415\u00a0years who received oral acyclovir (at 15\u00a0mg\/kg\/day) to prevent VZV reactivation after HSCT. We examined the cumulative incidence of VZV reactivation after HSCT, during and after prophylactic acyclovir administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three eligible patients were included in this study, of whom 37 underwent allogeneic HSCT. The median duration of prophylactic acyclovir therapy was 264\u00a0days (range: 69\u20131140\u00a0days). VZV reactivation occurred in 13 patients (24.5%, 95% confidence interval [CI]: 14.9\u201337.6). The cumulative incidence of VZV reactivation 1 and 2\u00a0years after HSCT was 6.26% (95% CI: 1.60\u201315.5) and 20.9% (95% CI: 10.3\u201334.0), respectively. While only one patient developed VZV reactivation during the administration of prophylactic acyclovir, the cumulative incidence of VZV reactivation increased to 24.2% (95% CI: 12.5\u201338.0) 1\u00a0year after the cessation of acyclovir.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010dose acyclovir (15\u00a0mg\/kg\/day) could be effective for preventing VZV reactivation after HSCT in children because VZV reactivation seldom occurs during the administration of 15\u00a0mg\/kg\/day acyclovir.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.29979","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T13:00:00Z","timestamp":1664024400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Low\u2010dose acyclovir for prophylaxis of varicella\u2010zoster virus reactivation after hematopoietic stem cell transplantation in children"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6711-2136","authenticated-orcid":false,"given":"Yasuhisa","family":"Tatebe","sequence":"first","affiliation":[{"name":"Department of Pharmacy Okayama University Hospital Kita\u2010ku  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Ushio","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Okayama University Hospital Kita\u2010ku  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Esumi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Okayama University Hospital Kita\u2010ku  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Sada","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Okayama University Hospital Kita\u2010ku  Okayama 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