{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:21:39Z","timestamp":1773685299108,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Biopsies for diagnosis before chemotherapy is common in children with malignant solid tumors. Wound healing is delayed by chemotherapy; however, the ideal interval between biopsy and chemotherapy remains unknown. We aimed to summarize the relationship between chemotherapy timing and postoperative surgical complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We retrospectively reviewed patients with malignant solid tumors who underwent chemotherapy after surgical biopsy at our institution between January 2014 and August 2020. The primary outcomes were postoperative surgical complications (within 30\u00a0days) and the timing of chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010three patients were analyzed. The types of tumors were neuroblastoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a020), hepatoblastoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a010), Ewing sarcoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a05), germ cell tumor (<jats:italic>n<\/jats:italic>\u00a0=\u00a03), angiosarcoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), clear cell sarcoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), ganglioneuroblastoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), rhabdoid tumor (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), and rhabdomyosarcoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a01). The operative procedures were thoracoscopy (<jats:italic>n<\/jats:italic>\u00a0=\u00a05), laparotomy (<jats:italic>n<\/jats:italic>\u00a0=\u00a017), laparoscopy (<jats:italic>n<\/jats:italic>\u00a0=\u00a014), and superficial (<jats:italic>n<\/jats:italic>\u00a0=\u00a07). The median time [range] to chemotherapy after biopsy was 4 [0\u201321] days. No surgical complications occurred before chemotherapy, and two (4.7%) patients experienced complications after chemotherapy. These included postoperative hemorrhage (grade 3) and surgical site infection (grade 1). Chemotherapy was initiated 1 and 6\u00a0days after biopsy, respectively, in these cases. Complications occurred 10 and 23\u00a0days after biopsy, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rate of postoperative surgical complications related to biopsy seems acceptable, even when chemotherapy was initiated in the early postoperative period. Early initiation of chemotherapy after biopsy may be a suitable option, particularly in children with bulky or symptomatic malignant solid tumors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30030","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T04:23:38Z","timestamp":1664771018000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Relationship between the timing of chemotherapy and surgical complications following surgical biopsy in children with malignant solid tumors"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8360-7630","authenticated-orcid":false,"given":"Kentaro","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Saitama Children's Medical Center  Saitama City Saitama Japan"},{"name":"Department of Pediatric Surgery, The University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Saitama Children's Medical Center  Saitama City Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youhei","family":"Sanmoto","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Saitama Children's Medical Center  Saitama City Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Oiki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Saitama Children's Medical Center  Saitama City Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Ishimaru","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Saitama Children's Medical Center  Saitama City Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Saitama Children's Medical Center  Saitama City Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Saitama Children's Medical Center  Saitama City Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Saitama Children's Medical Center  Saitama City Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpsurg.2017.11.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-021-04968-1"},{"key":"e_1_2_9_4_1","first-page":"988","article-title":"Effects of early postoperative chemotherapy on wound healing","volume":"79","author":"Kolb BA","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.05.015"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-021-04942-x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.03.040"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjoq-2020-000934"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.00449"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.06.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds236"},{"key":"e_1_2_9_13_1","unstructured":"Children's Oncology Group.Combination chemotherapy alone or with radiation therapy in treating children with kidney cancer.NIH; Published January 27 2003. Updated February 25 2021. Accessed February 25 2022.https:\/\/ClinicalTrials.gov\/show\/NCT00002611"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.27.5907"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.06.022"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00598-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950100505"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.05.051"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.30030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.30030","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.30030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T05:53:14Z","timestamp":1692510794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.30030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,2]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/pbc.30030"],"URL":"https:\/\/doi.org\/10.1002\/pbc.30030","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,2]]},"assertion":[{"value":"2022-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e30030"}}