{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:18:22Z","timestamp":1783966702908,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study was performed to describe the single\u2010center experience of deep vein thrombosis (DVT) in children with severe traumatic brain injury (sTBI) who were mechanically ventilated with a central line, and to identify potentially modifiable risk factors. It was hypothesized that children with DVT would have a longer duration of central venous line (CVL) and a higher use of hypertonic saline (HTS) compared to those without DVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure\/methods<\/jats:title><jats:p>This was a retrospective study of children (0\u201318\u00a0years) with sTBI, who were intubated, had a CVL, and a minimum intensive care unit (ICU) stay of 3\u00a0days. Children were analyzed by the presence or absence of DVT. HTS use was evaluated using milliliter per kilogram (ml\/kg) of 3% equivalents. Univariable and multivariable logistic regression models were used to determine which factors were associated with DVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010seven children met inclusion criteria, 23 (29.9%) had a DVT detected in an extremity. On univariable analysis, children with DVT identified in an extremity had prolonged CVL use (14 vs. 8.5\u00a0days, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.021) and longer duration of mechanical ventilation (15 vs. 10\u00a0days, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.013). HTS 3% equivalent ml\/kg was not different between groups. On multivariable analysis, mechanical ventilation duration was associated with DVT detection in an extremity, whereas neither CVL duration nor HTS use had an association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was a high incidence of extremity DVT detected in children with sTBI who received invasive mechanical ventilation and had a CVL. HTS administration was not associated with DVT detection in an extremity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30044","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T15:09:12Z","timestamp":1666019352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Catheter\u2010associated deep vein thrombosis in children with severe traumatic brain injury: A single\u2010center experience"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9531-9481","authenticated-orcid":false,"given":"Marlina E.","family":"Lovett","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Critical Care Medicine Nationwide Children's Hospital The Ohio State University School of Medicine  Columbus Ohio 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