{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:05:12Z","timestamp":1753869912272,"version":"3.41.2"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brain tumors are the most common solid malignancies and the leading cause of cancer\u2010related mortality in children. While numerous studies report on viral infections in children with hematologic malignancies and solid organ transplantation, epidemiologic data on the incidence and outcome of viral infections in pediatric patients with brain tumors treated with targeted therapies are still lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives\/study design<\/jats:title><jats:p>We retrospectively reviewed all children with brain tumors receiving targeted therapies in a primary or recurrent setting at the Medical University of Vienna from 2006 to 2021. Demographic variables, quantitative and qualitative parameters of possible infections, and treatment outcomes were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a0117), 36% of the patients developed at least one PCR\u2010proven viral infection. Respiratory and gastrointestinal tract infections were most common, with 31% and 25%, respectively. Central nervous system (CNS) infections occurred in approximately 10%, with an almost equal distribution of varicella\u2010zoster virus, John Cunningham virus (JCV), and enterovirus. Two patients tested PCR\u2010positive for SARS\u2010CoV\u20102 infection, with one virus\u2010related death caused by a SARS\u2010CoV\u20102\u2010related acute respiratory distress syndrome. Patients receiving bevacizumab or mTOR inhibitors seem to have a greater susceptibility to viral infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pediatric patients with brain tumors receiving targeted therapies have a higher risk of viral infections when compared to children receiving conventional chemotherapy or the general population, and life\u2010threatening infections can occur. Fast detection and upfront treatment are paramount to prevent life\u2010threatening infections in immunocompromised children suffering from brain tumors receiving targeted therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30065","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T17:10:56Z","timestamp":1667063456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Viral infections in pediatric brain tumor patients treated with targeted therapies"],"prefix":"10.1002","volume":"70","author":[{"given":"Lisa","family":"Mayr","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Comprehensive Cancer Center for Pediatrics Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Steinmaurer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and 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