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The patient was found to be heterozygous for the mutation <jats:italic>HGB2<\/jats:italic>:c.290T&gt;C, p.Leu97Pro, which we have termed hemoglobin (Hb) Wareham. This substitution is expected to generate an unstable hemoglobin with increased oxygen affinity based on the homologous mutation previously described in the beta globin gene, which is termed as Hb Debrousse. The patient fully recovered by 9 months of age as expected with the transition from fetal to adult hemoglobin.<\/jats:p>","DOI":"10.1002\/pbc.30067","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T14:47:30Z","timestamp":1666018050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transient neonatal hemolytic anemia due to the novel gamma globin gene mutation HBG2:C.290T&gt;C, p.Leu97Pro (hemoglobin Wareham)"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-2276","authenticated-orcid":false,"given":"Lev","family":"Gorfinkel","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Boston Children's Hospital\/Dana\u2010Farber Cancer Institute Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9185-3612","authenticated-orcid":false,"given":"Franziska","family":"Wachter","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Boston Children's Hospital\/Dana\u2010Farber Cancer Institute Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010yuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Departments of Medicine Pathology and Laboratory Medicine Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Hansbury","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Boston Children's Hospital\/Dana\u2010Farber Cancer Institute Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7057-6863","authenticated-orcid":false,"given":"David A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Boston Children's Hospital\/Dana\u2010Farber Cancer Institute Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Utah Health Sciences  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H. K.","family":"Chui","sequence":"additional","affiliation":[{"name":"Departments of Medicine Pathology and Laboratory Medicine Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-028X","authenticated-orcid":false,"given":"Alan B.","family":"Cantor","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Boston Children's Hospital\/Dana\u2010Farber Cancer Institute Harvard Medical School  Boston Massachusetts USA"},{"name":"Harvard Stem Cell Institute  Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Nathan and Oski's Hematology and Oncology of Infancy and Childhood","author":"Orkin SH"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011858"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt911"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12277"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(84)90472-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.11701"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199604)51:4<276::AID-AJH5>3.0.CO;2-T"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06033.x"},{"issue":"3","key":"e_1_2_9_12_1","first-page":"188","article-title":"Infantile pyknocytosis: a rare form of neonatal anemia","volume":"12","author":"Kraus D","year":"2010","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24731"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1959.02070020229009"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.30067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.30067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.30067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T05:55:57Z","timestamp":1692510957000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.30067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,17]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/pbc.30067"],"URL":"https:\/\/doi.org\/10.1002\/pbc.30067","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,17]]},"assertion":[{"value":"2022-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e30067"}}