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To align global management, we address these issues in this international HARMONIsation and CollAboration (HARMONICA) project. There are multiple knowledge gaps and opportunities for future research including: (1) utilization of advanced RT technologies, including intensity\u2010modulated RT, proton beam therapy, combined with image\u2010guided RT to reduce target volumes; (2) impact of molecular biomarkers including loss of heterozygosity at 1p, 16q, and 1q gain on RT indications; (3) mitigation of reproductive toxicity following RT; (4) promotion of RT late effects research; and (5) support to overcome challenges in RT utilization in low\u2010 and middle\u2010income countries where 90% of the world's children reside. Here, we outline current status and future directions for RT in pediatric renal tumors.<\/jats:p>","DOI":"10.1002\/pbc.30090","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T05:27:36Z","timestamp":1670563656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Harmonica consensus, controversies, and future directions in radiotherapy for pediatric Wilms tumors"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0585-1712","authenticated-orcid":false,"given":"Mary Frances","family":"McAleer","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Melchior","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Saarland University Hospital Homburg 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kalapurakal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33147"},{"issue":"2","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.28257","article-title":"Wilms tumor","volume":"68","author":"Pater L","year":"2021","journal-title":"Pediatr Blood Cancer"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27085"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.04.027"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62395-3"},{"key":"e_1_2_8_7_1","article-title":"Impact of postoperative 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