{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:30:45Z","timestamp":1785198645348,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertensive disorders of pregnancy (HDP) are associated with neonatal hematological disturbances, such as thrombocytopenia. The association of HDP to platelet counts in the context of extreme prematurity, to trends of platelet counts during neonatal hospitalization, and to frequency of platelet transfusions remain to be explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Retrospective study of infants born at less than 29\u00a0weeks born between 2015 and 2019. Platelet counts were collected on initial complete blood count, at 2\u00a0weeks, 32\u00a0weeks post\u2010menstrual age (PMA), 36\u00a0weeks PMA, and closest to discharge. We examined the association between HDP and platelet counts at each time point, frequency of platelet transfusions and intraventricular hemorrhage (IVH) grade 3 or more.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total 296 infants were included, 43 exposed to HDP. Infants exposed had lower platelet counts at each time point, as well as a higher prevalence of platelet less than 150\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L on one of the time points (32% vs. 65%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Infants exposed to maternal hypertension were more frequently exposed to platelet transfusions (63% vs. 18%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Mixed effect model demonstrated an association between HDP and a lower trend in platelet counts at each time point (\u03b2\u00a0=\u00a0\u221294\u00a0\u00d7\u00a010<jats:sup>3<\/jats:sup>\/\u03bcl, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Although initial platelet count was associated with severe IVH, it was not associated to exposure to HDP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Premature infants exposed to HDP have a higher prevalence of thrombocytopenia, increased frequency of platelet transfusion, and an altered trend in platelet counts during neonatal hospitalization.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30131","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T21:40:03Z","timestamp":1670449203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Thrombocytopenia and neonatal outcomes among extremely premature infants exposed to maternal hypertension"],"prefix":"10.1002","volume":"70","author":[{"given":"Joanne","family":"Delaney","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Hematology\u2010Oncology Montreal Children's Hospital, McGill University Health Centre, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6346-3649","authenticated-orcid":false,"given":"Gabriela De Carvalho","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Neonatology Montreal Children's Hospital, McGill University Health Centre, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Simoneau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Neonatology Montreal Children's Hospital, McGill University Health Centre, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Beltempo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Neonatology Montreal Children's Hospital, McGill University Health Centre, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Malham\u00e9","sequence":"additional","affiliation":[{"name":"Department of Medicine, General Internal Medicine McGill University Health Centre McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0670-3121","authenticated-orcid":false,"given":"Catherine","family":"Goudie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology\u2010Oncology Montreal Children's Hospital, McGill University Health Centre, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5141-0964","authenticated-orcid":false,"given":"Gabriel","family":"Altit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Neonatology Montreal Children's Hospital, McGill University Health Centre, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/214365"},{"issue":"7","key":"e_1_2_12_3_1","first-page":"1241","article-title":"Pregnancy induced hypertension versus small weight for gestational age: cause of neonatal hematological disorders","volume":"64","author":"Bizerea TO","year":"2018","journal-title":"Clin Lab"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(86)81059-9"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-008-0110-x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.141"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-59"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70413-2"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010197801000\u201000001"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2018.04.008"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489039"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-318594"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-536x.2001.00202.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-8-15"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-11-16"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08892.x"}],"container-title":["Pediatric Blood &amp; 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