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There is currently no consensus on the definition of rITP, nor evidence\u2010based treatment guidelines for patients with rITP. After a survey of pediatric ITP experts demonstrated lack of consensus on pediatric rITP, we pursued a systematic review to examine the reported clinical phenotypes and treatment outcomes in pediatric rITP. The search identified 253 relevant manuscripts; following review, 11 studies proposed a definition for pediatric rITP with no consensus amongst them. Most definitions included suboptimal response to medical management, while some outlined specific platelet thresholds to define this suboptimal response. Common attributes identified in this study should be used to propose a comprehensive definition, which will facilitate outcome comparisons of future rITP studies.<\/jats:p>","DOI":"10.1002\/pbc.30173","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T12:14:00Z","timestamp":1672316040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pediatric refractory immune thrombocytopenia: A systematic review"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0815-0006","authenticated-orcid":false,"given":"Layan","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5408-0200","authenticated-orcid":false,"given":"Selina 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