{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:37:32Z","timestamp":1789015052033,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An assay for neutrophil\u2010specific antibodies is frequently used in the workup of chronic severe neutropenia and is suggestive of autoimmune, or sporadically alloimmune neutropenia, rather than severe congenital neutropenia (SCN). We analyzed a neutropenia consortium database for the outcomes of antibody testing initiated before receiving genetic diagnosis in Polish SCN cohort. Test results, performed in a single reference laboratory, were available for 14 patients with ELANE\u2010mutated SCN or cyclic neutropenia, and were frequently positive (36%). We note that the trigger for genetic studies in severe neutropenia should not be affected by antibody\u2010positivity and should be clinically driven.<\/jats:p>","DOI":"10.1002\/pbc.30247","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T11:53:19Z","timestamp":1675425199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A high prevalence of neutrophil\u2010specific antibodies in ELANE\u2010mutated severe congenital neutropenia"],"prefix":"10.1002","volume":"70","author":[{"given":"Weronika","family":"Dobrewa","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Oncology and Haematology, Medical University of Lodz  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Madzio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oncology and Haematology, Medical University of Lodz  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Babol\u2010Pokora","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oncology and Haematology, Medical University of Lodz  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Lopacz","sequence":"additional","affiliation":[{"name":"Department of Hematological and Transfusion Immunology Institute of Hematology and Transfusion Medicine  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3092-5878","authenticated-orcid":false,"given":"Agnieszka","family":"Gierszon","sequence":"additional","affiliation":[{"name":"Department of Hematological and Transfusion Immunology Institute of Hematology and Transfusion Medicine  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2250-2226","authenticated-orcid":false,"given":"Katarzyna","family":"Guz","sequence":"additional","affiliation":[{"name":"Department of Hematological and Transfusion Immunology Institute of Hematology and Transfusion Medicine  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7306-0579","authenticated-orcid":false,"given":"Agnieszka","family":"Orzinska","sequence":"additional","affiliation":[{"name":"Department of Hematological and Transfusion Immunology Institute of Hematology and Transfusion Medicine  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Uhrynowska","sequence":"additional","affiliation":[{"name":"Department of Hematological and Transfusion Immunology Institute of Hematology and Transfusion Medicine  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Jasinska","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oncology and Haematology, Medical University of Lodz  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Zdunek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oncology and Haematology, Medical University of Lodz  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Mlynarski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oncology and Haematology, Medical University of Lodz  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8007-6969","authenticated-orcid":false,"given":"Szymon","family":"Janczar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oncology and Haematology, Medical University of Lodz  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-26"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14887"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2021.1976634"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14677"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29599"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620714556642"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V126.23.2211.2211"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2007.00890.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2007.00920.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-016-0294-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26625"}],"container-title":["Pediatric Blood &amp; 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