{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:31:22Z","timestamp":1754159482768,"version":"3.41.2"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012095","name":"Scottish Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patterns and risks of subsequent primary tumours (SPTs) among long\u2010term survivors of childhood cancer have been extensively described, but much less is known about early SPTs (ESPTs) occurring within 5 years after initial diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We carried out a population\u2010based study of ESPTs following childhood cancer throughout Britain, using the National Registry of Childhood Tumours. The full study series comprised all ESPTs occurring among 56,620 children whose initial cancer diagnosis was in the period 1971\u20132010. Frequencies of ESPT were calculated for the entire cohort. For analyses of risk, follow\u2010up began 92\u00a0days after initial diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ESPT developed in 0.4% of children overall, 0.52% of those initially diagnosed at age less than 1\u00a0year and 0.38% of those diagnosed at age 1\u201314\u00a0years. Standardised incidence ratio (SIR) was 7.7 (95% confidence interval [CI]: 6.7\u20138.9), overall 9.5 (95% CI: 7.1\u201312.5) for children initially diagnosed in 1981\u20131990 and 6.5\u20137.5 for those from earlier and later decades. SIR by type of first cancer ranged from 4.4 (95% CI: 1.8\u20139.1) for Wilms tumour to 13.1 (95% CI: 7.7\u201321.0) for non\u2010Hodgkin lymphoma. SIR by type of ESPT ranged from 2.0 (95% CI: 1.0\u20133.4) for acute lymphoblastic leukaemia to 66.6 (95% CI: 52.3\u201383.6) for acute myeloid leukaemia. Predisposition syndromes were known to be implicated in 21% of children with ESPT and suspected in another 5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides an overview of the patterns and risks of ESPTs in a large population where many children received therapy that is still in widespread use. Further research will be needed to monitor and understand changes in risk as childhood cancer treatment continues to evolve.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30258","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T06:33:44Z","timestamp":1677134024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Subsequent cancers within 5\u00a0years from initial diagnosis of childhood cancer. Patterns and risks in the population of Great Britain"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3006-7869","authenticated-orcid":false,"given":"Charles A.","family":"Stiller","sequence":"first","affiliation":[{"name":"National Disease Registration Service NHS England  Didcot UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn J.","family":"Bunch","sequence":"additional","affiliation":[{"name":"National Perinatal Epidemiology Unit Nuffield Department of Population Health University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita M.","family":"Bayne","sequence":"additional","affiliation":[{"name":"National Disease Registration Service NHS England  Didcot UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C. 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