{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:21:43Z","timestamp":1784280103143,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01HL133996\u201004"],"award-info":[{"award-number":["U01HL133996\u201004"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate attitudes toward vaccination and vaccine uptake regarding coronavirus disease 2019 (COVID\u201019) among pediatric patients with sickle cell disease (SCD) and their caregivers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Adolescent patients and caregivers of children with SCD were surveyed during routine clinic visits; we then conducted a logistic regression analysis to understand differences in vaccine status, while qualitative responses were coded thematically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among respondents, the overall vaccination rate among adolescents and caregivers was 49% and 52%, respectively. Among the unvaccinated, 60% and 68% of adolescents and caregivers, respectively, preferred to remain unvaccinated, most commonly due to lack of perceived personal benefit from vaccination or mistrust in the vaccine. Multivariate logistic regression analysis showed that child's age (odds ratio [OR]\u00a0=\u00a01.1, 95% confidence interval [CI]: 1.0\u20131.2, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) and caregiver education (measured by the Economic Hardship Index [EHI] score, OR\u00a0=\u00a00.76, 95% CI: 0.74\u20130.78, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) were independent predictors of getting vaccinated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the increased risk of severe illness due to COVID\u201019 in patients with SCD, vaccine hesitancy remains high in this population of families whose children have SCD. Fortunately, the reasons cited for deferring vaccination among those who are unvaccinated were largely due to barriers that may be overcome with quality communication around the utility of the vaccine and information about vaccine safety.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30274","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T01:00:47Z","timestamp":1677718847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Attitudes toward COVID\u201019 vaccine among pediatric patients with sickle cell disease and their caregivers"],"prefix":"10.1002","volume":"70","author":[{"given":"Yogindra","family":"Persaud","sequence":"first","affiliation":[{"name":"Department of Hematology St Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Hospitalist Division St Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda N.","family":"Mandrell","sequence":"additional","affiliation":[{"name":"Division of Nursing Research St Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3281-2081","authenticated-orcid":false,"given":"Akshay","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplant and Cellular Therapy St Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Hematology St Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Irvine","sequence":"additional","affiliation":[{"name":"Hospitalist Division St Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunusa","family":"Olufadi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolian","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego R.","family":"Hijano","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease St Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Hematology St Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-7321","authenticated-orcid":false,"given":"Jane S.","family":"Hankins","sequence":"additional","affiliation":[{"name":"Department of Hematology St Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7124-979X","authenticated-orcid":false,"given":"Liza\u2010Marie","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Hematology St Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Department of Oncology St Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004288"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23627"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21570"},{"key":"e_1_2_10_5_1","unstructured":"NduggaN HillL ArtigaS HaldarS.Latest data on COVID\u201019 vaccinations by race\/ethnicity.KFF; Published July 14 2022. 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