{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:12:40Z","timestamp":1790878360053,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K23HL140142"],"award-info":[{"award-number":["1K23HL140142"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K23HL140142\u201003S1"],"award-info":[{"award-number":["1K23HL140142\u201003S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allogeneic hematopoietic stem cell transplantation (HCT) performed in children from human leukocyte antigen (HLA)\u2010identical related donors is associated with very high survival rates and disease\u2010free survival. Patients are exposed to gonadotoxic alkylating agents or irradiation in the HCT conditioning regimen. Consequently, infertility is a major long\u2010term complication of HCT for sickle cell disease (SCD). We sought to understand how caregivers perceive the risk of infertility from HCT, how they perceive the options for fertility preservation, and how this risk perception impacted their decision\u2010making to pursue HCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>We conducted qualitative interviews with primary caregivers after a consultation for HCT for SCD. Data were analyzed using descriptive qualitative analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We interviewed 19 primary caregivers who had attended a consultation with an HCT physician (female, age 25\u201359 [median 39] years). Eleven participants reported that their child had an available HLA\u2010matched donor. Analysis revealed that (i) mothers were worried about death and graft\u2010versus\u2010host disease from HCT, more than about the risk of infertility; (ii) parents have a realistic understanding of the risk of infertility after HCT and take it into consideration in decision\u2010making; (iii) parents report multiple barriers to fertility preservation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For parents actively considering HCT for their child with SCD, the risk of infertility while important was not a barrier to pursuing HCT. Inconvenience and invasiveness of fertility preservation procedures are some of the barriers to pursuing fertility preservation for their child. Future research must aim at addressing these barriers to fertility preservation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30276","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T07:51:12Z","timestamp":1681372272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Parental perspective on the risk of infertility and fertility preservation options for children and adolescents with sickle cell disease considering hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"70","author":[{"given":"Cynthia B.","family":"Sinha","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology\u2010BMT Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian R.","family":"Meacham","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology\u2010BMT Emory University  Atlanta Georgia USA"},{"name":"Aflac Cancer and Blood Disorders Children's healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0876-9506","authenticated-orcid":false,"given":"Nitya","family":"Bakshi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology\u2010BMT Emory University  Atlanta Georgia USA"},{"name":"Aflac Cancer and Blood Disorders Children's healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology\u2010BMT Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-0037","authenticated-orcid":false,"given":"Lakshmanan","family":"Krishnamurti","sequence":"additional","affiliation":[{"name":"Yale Pediatric Hematology &amp; 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