{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:31:27Z","timestamp":1754159487833,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diffuse large B\u2010cell lymphoma (DLBCL) is classified into two molecular subtypes according to its cell of origin: germinal center B\u2010cell (GCB) subtype and activated B\u2010cell\/non\u2010GCB subtype. This latter subtype shows a poorer prognosis in adults. However, in pediatric DLBCL, the prognostic impact of the subtype is yet to be clarified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study sought to compare the prognosis between GCB and non\u2010GCB DLBCL in a large number of cases in children and adolescents. In addition, this study intended to describe the clinical, immunohistochemical, and cytogenetic characteristics of these two molecular subtypes of DLBCL, and consider differences in the biology, frequency, and prognosis of GCB and non\u2010GCB subtypes in pediatric versus adult DLBCL or in Japanese versus Western pediatric DLBCL patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/methods<\/jats:title><jats:p>We selected mature B\u2010cell lymphoma\/leukemia patients for whom specimens had been submitted to the central pathology review in Japan between June 2005 and November 2019. We referred the past studies on Asian adult patients and Western pediatric patients to compare with our results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were obtained from 199 DLBCL patients. The median age of all patients was 10\u00a0years, with 125 patients (62.8%) in the GCB group and 49 (24.6%) in the non\u2010GCB group other than 25 cases whose immunohistochemical data were insufficient. Overall, the percentage of translocation of <jats:italic>MYC<\/jats:italic> (1.4%) and <jats:italic>BCL6<\/jats:italic> (6.3%) was lower than in adult and Western pediatric DLBCL cases. The non\u2010GCB group showed a significantly higher proportion of females (44.9%), a higher incidence of stage III disease (38.8%), and B\u2010cell lymphoma 2 (BCL2)\u2010positivity in immunohistochemistry (79.6%) compared to the GCB group; however, no <jats:italic>BCL2<\/jats:italic> rearrangement was observed in both GCB and non\u2010GCB groups. The prognosis did not differ significantly between the GCB and non\u2010GCB groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study including a large number of non\u2010GCB patients showed the same prognosis between GCB and non\u2010GCB groups and suggested a difference in the biology of pediatric and adolescent DLBCL compared to adult DLBCL as well as between Asian and Western DLBCL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30279","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T01:31:27Z","timestamp":1677720687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non\u2010germinal center B\u2010cell subtype of pediatric diffuse large B\u2010cell lymphoma in Japan: A retrospective cohort study"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0634-6961","authenticated-orcid":false,"given":"Daiki","family":"Hori","sequence":"first","affiliation":[{"name":"Lymphoma and Pathology Committee JCCG (Japan Children's Cancer Group)\/JPLSG (Japan Pediatric Leukemia\/Lymphoma Study Group)  Tokyo Japan"},{"name":"Department of Hematology\/Oncology for Children and Adolescents Sapporo Hokuyu Hospital  Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-0856","authenticated-orcid":false,"given":"Ryoji","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Lymphoma and Pathology Committee JCCG (Japan Children's Cancer Group)\/JPLSG (Japan Pediatric Leukemia\/Lymphoma Study Group)  Tokyo Japan"},{"name":"Department of Hematology\/Oncology for Children and Adolescents Sapporo Hokuyu Hospital  Sapporo Hokkaido 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(Japan Children's Cancer Group)\/JPLSG (Japan Pediatric Leukemia\/Lymphoma Study Group)  Tokyo Japan"},{"name":"Department of Pediatrics National Hospital Organization Nagoya Medical Center  Nagoya 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