{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:36:32Z","timestamp":1789011392960,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>IKZF1<\/jats:italic> gene deletion is an indicator of poor prognosis in childhood B\u2010cell precursor acute lymphoblastic leukemia (BCP\u2010ALL). The AEIOP\/BFM group proposed that the prognostic strength of <jats:italic>IKZF1<\/jats:italic> deletion could be remarkably improved by taking into account additional genetic deletions and reported that among patients with an <jats:italic>IKZF1<\/jats:italic> deletion those with deletions in <jats:italic>CDKN2A\/2B<\/jats:italic>, <jats:italic>PAX5<\/jats:italic>, or PAR1 in the absence of <jats:italic>ERG<\/jats:italic> deletion, grouped as IKZF1<jats:sup>plus<\/jats:sup>, had the worst outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Between 1998 and 2008, 1636 patients under 18 years of age with previously untreated BCP\u2010ALL were registered in the EORTC 58951 trial. Those with multiplex ligation\u2010dependent probe amplification data were included in this analysis. Unadjusted and adjusted Cox model was used to investigate the additional prognostic value of IKZF1<jats:sup>plus<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1200 patients included in the analysis, 1039 (87%) had no <jats:italic>IKZF1<\/jats:italic> deletion (IKZF1<jats:sup>WT<\/jats:sup>), 87 (7%) had an <jats:italic>IKZF1<\/jats:italic> deletion but not IKZF1<jats:sup>plus<\/jats:sup> (IKZF1<jats:sup>del<\/jats:sup>) and 74 (6%) had IKZF1<jats:sup>plus<\/jats:sup>. In the unadjusted analysis, both patients with IKZF1<jats:sup>del<\/jats:sup> (hazard ratio [HR]\u00a0=\u00a02.10, 95% confidence interval [CI]: 1.34\u20133.31) and IKZF1<jats:sup>plus<\/jats:sup> (HR\u00a0=\u00a03.07, 95% CI: 2.01\u20134.67) had a shorter event\u2010free survival compared with IKZF1<jats:sup>WT<\/jats:sup>. However, although the IKZF1<jats:sup>plus<\/jats:sup> status was associated with patients\u2019 characteristics indicating poor prognosis, the difference between IKZF1<jats:sup>plus<\/jats:sup> and IKZF1<jats:sup>del<\/jats:sup> was not statistically significant (HR\u00a0=\u00a01.46, 95% CI: 0.83\u20132.57, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.19). The results of the adjusted analysis were similar to the unadjusted analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with BCP\u2010ALL from the EORTC 58951 trial, the improvement of the prognostic importance of <jats:italic>IKZF1<\/jats:italic> by considering IKZF1<jats:sup>plus<\/jats:sup> was not statistically significant.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30313","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T13:00:37Z","timestamp":1679922037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The prognostic value of IKZF1<sup>plus<\/sup> in B\u2010cell progenitor acute lymphoblastic leukemia: Results from the EORTC 58951 trial"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7066-0587","authenticated-orcid":false,"given":"Michal","family":"Kicinski","sequence":"first","affiliation":[{"name":"EORTC Headquarters  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9345-4268","authenticated-orcid":false,"given":"Chlo\u00e9","family":"Arfeuille","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique H\u00f4pital Robert Debr\u00e9, Assistance Publique des H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"INSERM, UMR_S1131 Institut de Recherche Saint\u2010Louis, Universit\u00e9 Paris\u2010Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Grardel","sequence":"additional","affiliation":[{"name":"Haematology laboratory CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen","family":"Bakkus","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Haematology University Hospital Brussels, Vrije Universiteit Brussel (VUB)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5996-3037","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Caye\u2010Eude","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique H\u00f4pital Robert Debr\u00e9, Assistance Publique des H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"INSERM, UMR_S1131 Institut de Recherche Saint\u2010Louis, Universit\u00e9 Paris\u2010Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Plat","sequence":"additional","affiliation":[{"name":"Department of Hematology CHU Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Ferster","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology HUDERF (ULB)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Uyttebroeck","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato\u2010Oncology University Hospital Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2449-539X","authenticated-orcid":false,"given":"Barbara","family":"De Moerloose","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Rohrlich","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology CHU Nice  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Suciu","sequence":"additional","affiliation":[{"name":"EORTC Headquarters  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Institut d'H\u00e9matologie et d'Oncologie P\u00e9diatrique Hospices Civils de Lyon, Universit\u00e9 Lyon Lyon  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2840-1511","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Cav\u00e9","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique H\u00f4pital Robert Debr\u00e9, Assistance Publique des H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"INSERM, UMR_S1131 Institut de Recherche Saint\u2010Louis, Universit\u00e9 Paris\u2010Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/EHM.11.8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/ASHEDUCATION\u20102014.1.190"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/HAEMATOL.2020.247031"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PCL.2014.09.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000245"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA0808253"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BLRE.2020.100677"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000813"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(08)70339\u20105"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.3617"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.134"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/HAEMATOL.2014.103507"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD\u20102009\u201010\u2010247965"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201006\u2010437681"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/SJ.LEU.2402396"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2307\/2670170"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.6408"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/LEU.2010.87"},{"issue":"7","key":"e_1_2_9_21_1","first-page":"881","article-title":"The prognostic significance of CDKN2A, CDKN2B and MTAP inactivation in B\u2010lineage acute lymphoblastic leukemia of childhood. Results of the EORTC studies 58881 and 58951","volume":"91","author":"Mirebeau D","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.277"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.282"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.30313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T03:40:35Z","timestamp":1722570035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.30313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,27]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/pbc.30313"],"URL":"https:\/\/doi.org\/10.1002\/pbc.30313","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,27]]},"assertion":[{"value":"2022-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e30313"}}