{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:29:26Z","timestamp":1790666966725,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intensive chemotherapy for acute lymphoblastic leukemia (ALL) may affect the immune system and potentially the immune memory causing antibodies provided by vaccination to disappear. There are disagreements regarding the guidelines for posttreatment immunization strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010six children (aged 1\u201318 years at diagnosis) who completed chemotherapy for ALL were recruited. Antibody levels in the patient's serum against measles, varicella, polio, pertussis, hepatitis A, and hepatitis B were tested after completion of chemotherapy in patients who were fully vaccinated against these agents. Children who did not have positive serology to specific agents were revaccinated with a single dose accordingly. Antibody concentrations were measured again at least 4\u00a0weeks after revaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Positive antibody levels varied between the different agents. The highest percentage of positive serology was against polio (87%) and the lowest against pertussis (4%) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). There were significant differences between patients with high risk (HR) and non\u2010HR ALL regarding serology status for some vaccines. After revaccination, the levels of response to each booster dose were significantly different: 100% after booster dose for varicella and polio, and only 34% after pertussis booster.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Loss of humoral protection for vaccine preventable diseases is a common finding among patients with ALL. Revaccination with one dose of vaccine after completion of chemotherapy achieved seroconversion in 34\u2013100% of the patients depending on the type of vaccine. We recommend this revaccination schedule to all children who completed ALL therapy and were previously fully vaccinated.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30321","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T13:20:49Z","timestamp":1681132849000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Revaccination of children with acute lymphoblastic leukemia following completion of chemotherapy"],"prefix":"10.1002","volume":"70","author":[{"given":"Adi","family":"Anafy","sequence":"first","affiliation":[{"name":"Department of Pediatrics Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Gilad","sequence":"additional","affiliation":[{"name":"Pediatric Hemato\u2010oncology Department Schneider Children's Medical Center, both centers affiliated to the Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadav","family":"Michaan","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5663-6919","authenticated-orcid":false,"given":"Ronit","family":"Elhasid","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato\u2010oncology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hila","family":"Rosenfeld\u2010Kaidar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato\u2010oncology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nira","family":"Arad\u2010Cohen","sequence":"additional","affiliation":[{"name":"Pediatric Hemato\u2010oncology Department, affiliated to the Ruth &amp; Bruce Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moran Szwarcwort","family":"Cohen","sequence":"additional","affiliation":[{"name":"Virology Laboratory, affiliated to the Ruth &amp; Bruce Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8353-0108","authenticated-orcid":false,"given":"Yael","family":"Shachor\u2010Meyouhas","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit and Management Rambam Health Care Campus affiliated to the Ruth &amp; Bruce Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9242-9423","authenticated-orcid":false,"given":"Galia","family":"Grisaru\u2010Soen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Disease Unit, Tel Aviv Sourasky Medical Center Dana\u2010Dwek Children's Hospital  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/511636"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2020.1802975"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22256"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit816"},{"key":"e_1_2_10_6_1","volume-title":"Immunisation of the immunocompromised child\u2014Best practice statement","author":"Royal College of Paediatrics and Child Health (RCPCH)","year":"2002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22415"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22256"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20120065"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2013.877111"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880011003767720"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30601-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32835d7d85"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2016.04.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2020.014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/707691"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404326"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2022.2137145"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.864674"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001072"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.6.e91"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2018.1460035"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08522.x"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.30321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T03:41:30Z","timestamp":1722570090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.30321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,10]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/pbc.30321"],"URL":"https:\/\/doi.org\/10.1002\/pbc.30321","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,10]]},"assertion":[{"value":"2022-12-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e30321"}}