{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:45:10Z","timestamp":1789591510427,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nutritional deficiencies are prevalent in sickle cell disease (SCD) and may be associated with worse pain outcomes. Gut dysbiosis has been reported in patients with SCD and may contribute to both nutritional deficiencies and pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We tested the association of nutrition, fat\u2010soluble vitamin (FSV) deficiency, and gut microbiome composition on clinical outcomes in SCD. Second, we measured the association between diet and exocrine pancreatic function on FSV levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using case control design, we enrolled children with SCD (<jats:italic>n<\/jats:italic>\u00a0=\u00a024) and matched healthy controls (HC; <jats:italic>n<\/jats:italic>\u00a0=\u00a017, age, sex, race\/ethnicity). Descriptive statistics summarized demographic and clinical data. Wilcoxson\u2010rank tests compared FSV levels between cohorts. Regression modeling tested the association between FSV levels and SCD status. Welch's <jats:italic>t<\/jats:italic>\u2010test with Satterthwaite adjustment evaluated associations between microbiota profiles, SCD status, and pain outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vitamin A and D levels were significantly decreased in participants with HbSS as compared to HC (vitamin A, <jats:italic>p<\/jats:italic>\u00a0=\u00a0&lt;\u00a0.0001, vitamin D, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.014) independent of nutritional status. FSV correlated with dietary intake in SCD and HC cohorts. Gut microbial diversity was reduced in hemoglobin SS (HbSS) compared to hemoglobin SC (HbSC) and HC, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.037 and .059, respectively. The phyla <jats:italic>Erysipelotrichaceae<\/jats:italic> and <jats:italic>Betaproteobacteria<\/jats:italic> were higher in SCD children reporting the highest quality\u2010of\u2010life (QoL) scores (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.008 and .049, respectively), while <jats:italic>Clostridia<\/jats:italic> were higher in those with lower QoL scores (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FSV deficiencies and gut dysbiosis are prevalent in children with SCA. Gut microbial composition is significantly different in children with SCD with low QoL scores.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30397","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T04:54:07Z","timestamp":1682571247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The relationship between nutrition, gut dysbiosis, and pediatric sickle cell pain outcomes: A pilot study"],"prefix":"10.1002","volume":"70","author":[{"given":"Chinenye R.","family":"Dike","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Gastroenterology, Hepatology and Nutrition University of Nebraska Medical Center and Children's Hospital &amp; Medical Center  Omaha Nebraska USA"},{"name":"Department of Pediatrics Division of Pediatric Gastroenterology, Hepatology and Nutrition University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrine","family":"Hanson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Division of Medical Nutrition University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Dele","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Infectious Diseases University of Nebraska Medical Center and Children's Hospital &amp; Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Obaro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Infectious Diseases University of Nebraska Medical Center and Children's Hospital &amp; Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Nebraska Medical Center and Children's Hospital &amp; Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Harper","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology and Oncology University of Nebraska Medical Center and Children's Hospital &amp; Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Grace","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of General Pediatrics University of Nebraska Medical Center and Children's Hospital &amp; Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Lebensburger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology and Oncology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chittalsinh","family":"Raulji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology and Oncology University of Nebraska Medical Center and Children's Hospital &amp; Medical Center  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