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Outcomes are favorable following treatment modeled after acute lymphoblastic leukemia (ALL) regimens, but prognosis is dismal after relapse, and there are no established features for predicting therapy response. Ongoing US and international trials will include the largest cohort of uniformly treated patients with B\u2010LLy to date, providing an opportunity to define clinical and molecular predictors of relapse and to establish a standard of care for treatment to improve outcomes for this rare pediatric cancer.<\/jats:p>","DOI":"10.1002\/pbc.30401","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T17:52:05Z","timestamp":1683741125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["How I approach B\u2010lymphoblastic lymphoma in children"],"prefix":"10.1002","volume":"70","author":[{"given":"Kaitlin J.","family":"Devine","sequence":"first","affiliation":[{"name":"Division of Oncology The Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5436-7356","authenticated-orcid":false,"given":"Carol","family":"Fries","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\/Oncology University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Hermiston","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\/Oncology University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte","family":"Wistinghausen","sequence":"additional","affiliation":[{"name":"Division of Oncology Center for Cancer and Blood Disorders Children's National Hospital  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14163895"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26363"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12460"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2010.08541.x"},{"key":"e_1_2_11_6_1","unstructured":"Special section: cancer in children and adolescents. 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