{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:20:21Z","timestamp":1779898821481,"version":"3.53.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Global Registry of COVID\u201019 in Childhood Cancer (GRCCC) seeks to describe the natural history of SARS\u2010CoV\u20102 in children with cancer across the world. Here, we report the disease course and management of coronavirus disease 2019 (COVID\u201019) infection in the subset of children and adolescents with central nervous system (CNS) tumors who were included in the GRCCC until February 2021, the first data freeze.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>The GRCCC is a deidentified web\u2010based registry of patients less than 19\u00a0years of age with cancer or recipients of a hematopoietic stem cell transplant and laboratory\u2010confirmed SARS\u2010CoV\u20102 infection. Demographic data, cancer diagnosis, cancer\u2010directed therapy, and clinical characteristics of SARS\u2010CoV\u20102 infection were collected. Outcomes were collected at 30 and 60\u00a0days post infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The GRCCC included 1500 cases from 45 countries, including 126 children with CNS tumors (8.4%). Sixty percent of the cases were from middle\u2010income countries, while no cases were reported from low\u2010income countries. Low\u2010grade gliomas, high\u2010grade gliomas, and CNS embryonal tumors were the most common CNS cancer diagnoses (67%, 84\/126). Follow\u2010up at 30\u00a0days was available for 107 (85%) patients. Based on the composite measure of severity, 53.3% (57\/107) of reported SARS\u2010CoV\u20102 infections were asymptomatic, 39.3% (42\/107) were mild\/moderate, and 6.5% (7\/107) were severe or critical. One patient died from SARS\u2010CoV\u20102 infection. There was a significant association between infection severity and absolute neutrophil count less than 500 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.04). Of 107 patients with follow\u2010up available, 40 patients (37.4%) were not receiving cancer\u2010directed therapy. Thirty\u2010four patients (50.7%) had a modification to their treatment due to withholding of chemotherapy or delays in radiotherapy or surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this cohort of patients with CNS tumors and COVID\u201019, the frequency of severe infection appears to be low, although severe disease and death do occur. We found that greater severity was seen in patients with severe neutropenia, although treatment modifications were not associated with infection severity or cytopenias. Additional analyses are needed to further describe this unique group of patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30402","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T08:28:10Z","timestamp":1684312090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of SARS\u2010CoV\u20102 infection in 126 children and adolescents with central nervous system tumors"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-156X","authenticated-orcid":false,"given":"Daniel C.","family":"Moreira","sequence":"first","affiliation":[{"name":"St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6645-4895","authenticated-orcid":false,"given":"Ibrahim","family":"Qaddoumi","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Chen","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nickhill","family":"Bhakta","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo L.","family":"Chantada","sequence":"additional","affiliation":[{"name":"Fundacion P\u00e9rez Scremini\u2010Hospital Pereira Rossell  Montevideo Uruguay"},{"name":"Hospital Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M.","family":"Santana","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-9605","authenticated-orcid":false,"given":"Miguela A.","family":"Caniza","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Devidas","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2384-9475","authenticated-orcid":false,"given":"Kathy","family":"Pritchard\u2010Jones","sequence":"additional","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2360-8946","authenticated-orcid":false,"given":"Carlos","family":"Rodriguez\u2010Galindo","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-6539","authenticated-orcid":false,"given":"Eric","family":"Bouffet","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Kids  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5435-3707","authenticated-orcid":false,"given":"Sheena","family":"Mukkada","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Global Registry of COVID\u201019 in Childhood 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