{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:28Z","timestamp":1786978348717,"version":"build-2736575974"},"reference-count":8,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Targeted therapy has become the first therapeutic option in many patients with vascular anomalies. A male 28\u2010year\u2010old patient presented a severe cervicofacial venous malformation involving half\u2010lower face, anterior neck, and oral cavity with progression despite multiple previous treatments, with a somatic variant in\n                    <jats:italic>TEK<\/jats:italic>\n                    (endothelial\u2010specific protein receptor tyrosine kinase) (c.2740C&gt;T; p.Leu914Phe). The patient had facial deformity, daily episodes of pain and inflammation needing massive amount of medication, and difficulty in speech and swallowing, so rebastinib (a TIE2 kinase inhibitor) was approved for compassionate use. After 6\u00a0months of treatment, venous malformation had decreased in size and lightened, as well as improved quality\u2010of\u2010life scores.\n                  <\/jats:p>","DOI":"10.1002\/pbc.30404","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T13:39:16Z","timestamp":1683725956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Activity of a TIE2 inhibitor (rebastinib) in a patient with a life\u2010threatening cervicofacial venous malformation"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8176-6010","authenticated-orcid":false,"given":"Paloma","family":"Triana","sequence":"first","affiliation":[{"name":"Vascular Anomaly Center La Paz Children's Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Lopez\u2010Gutierrez","sequence":"additional","affiliation":[{"name":"Vascular Anomaly Center La Paz Children's Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"3","article-title":"Drug treatment of vascular anomalies","volume":"33","author":"Triana P","year":"2020","journal-title":"Cir Pediatr"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.11.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.3459"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-13-72"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-0241"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.152710"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.TARG\u201019\u2010B055"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.08.672"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.30404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T17:03:27Z","timestamp":1692464607000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.30404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,9]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/pbc.30404"],"URL":"https:\/\/doi.org\/10.1002\/pbc.30404","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,9]]},"assertion":[{"value":"2023-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e30404"}}