{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:16:14Z","timestamp":1774458974541,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Brainstem tumors comprise 10.9% of all brain tumors, and pediatric diffuse intrinsic pontine gliomas (DIPG) have a fatal prognosis. Some countries have developed national and international register databases to characterize their populations to aid clinical and public policy decisions. This study provides information regarding the clinical characteristics of a retrospective cohort of children with DIPG in M\u00e9xico from 2001 to 2021, and assesses the proposed prognostic factors previously described for survival outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Health institutions from Mexico were invited to contribute to a retrospective electronic registry of patients with DIPG based on the International DIPG Registry. Fisher's exact test was used to compare long\u2010 and short\u2010term survivors. Overall survival was estimated using the Kaplan\u2013Meier method. Differences between survival curves were evaluated using the log\u2010rank test and Cox proportional hazard regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total 110 patients were included. The median age of the patients at diagnosis was 7\u00a0years. Sixty patients (54.5%) presented with symptoms in less than 6\u00a0months; the most frequent symptom was ataxia (56.4%). Ninety patients received treatment (81.8%), the overall survival at 4\u00a0years was 11.4%, and 16 patients (14.5%) were admitted for palliative end\u2010of\u2010life care. We found no significant survival differences for any of the prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the need to develop strategies to standardize healthcare processes and enhance the quality of care to improve clinical diagnosis in Mexico. We also observed a barrier to the acceptance of palliative end\u2010of\u2010life care in the family and medical teams.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30431","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T07:29:48Z","timestamp":1686122988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diffuse intrinsic pontine gliomas: First registry effort in Mexico"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2498-7386","authenticated-orcid":false,"given":"Julieta","family":"Robles\u2010Castro","sequence":"first","affiliation":[{"name":"Hospital Central Sur de Alta Especialidad de Petr\u00f3leos Mexicanos  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Niembro\u2010Z\u00fa\u00f1iga","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Pediatr\u00eda  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Ortiz\u2010Azpilcueta","sequence":"additional","affiliation":[{"name":"Hospital Siglo XXI Instituto Mexicano del Seguro Social (IMSS)  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadira","family":"Betanzos\u2010Cabrera","sequence":"additional","affiliation":[{"name":"Hospital Siglo XXI Instituto Mexicano del Seguro Social (IMSS)  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farina","family":"Arregu\u00edn\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico Nacional 20 de Noviembre Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE)  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Barrera\u2010Villegas","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico Nacional 20 de Noviembre Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE)  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ortiz\u2010Morales","sequence":"additional","affiliation":[{"name":"Hospital Eduardo Liceaga Hospital General de M\u00e9xico  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Benjam\u00edn","family":"Arroyo\u2010Acosta","sequence":"additional","affiliation":[{"name":"Hospital CIMA  Hermosillo Sonora M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Zapata\u2010Tarr\u00e9s","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n de Investigaci\u00f3n Fundaci\u00f3n IMSS, A.C.  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