{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:04:34Z","timestamp":1753869874799,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dysregulation of microRNAs (miRNAs) targeting genes in the PI3K\/Akt pathway has been implicated in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). However, the impact of genetic variants in these miRNAs on ALL susceptibility has not been extensively explored in the Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To address this gap, we conducted a case\u2013control study to evaluate the association between genetic variants in five PI3K\/AKT pathway\u2010related miRNAs (miR\u2010149, miR\u2010126, miR\u2010492, miR\u2010612, and miR\u2010423) and childhood ALL susceptibility in the Chinese population. Additionally, we investigated the effects of the rs2292832 mutation on ALL cell proliferation and apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our analyses revealed that the miR\u2010149 rs2292832 mutant heterozygous CT genotype was more frequent in the control group than in the ALL cases, indicating a protective effect against ALL (adjusted odds ratio [OR]\u00a0=\u00a00.78, 95% confidence interval [CI]\u00a0=\u00a00.63\u20130.97, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.024). Stratification analyses further revealed that the miR\u2010149 rs2292832 CC genotype was associated with an increased risk of childhood ALL in subgroups of older children, females, those with parents who never smoked or drank alcohol, those living in painted houses, those with B\u2010ALL, and those with high\u2010risk ALL. Finally, we observed that the rs2292832 mutation inhibited ALL cell proliferation and induced apoptosis (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001), providing a potential mechanism by which this genetic variant may influence ALL susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study highlights the significant association between the miR\u2010149 rs2292832 genetic variant and childhood ALL susceptibility in the Chinese population. These findings expand our understanding of the complex genetic landscape underlying ALL and have implications for the development of personalized therapeutic strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30545","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T03:39:26Z","timestamp":1689219566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["PI3K\/AKT pathway\u2010related microRNA variants in childhood acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"70","author":[{"given":"Yao","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Children's Hospital of Nanjing Medical University Nanjing China"},{"name":"Key Laboratory of Hematology Nanjing Medical University Nanjing 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