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Improvements in survival in NHL over the past 5 decades align with the overall success of the cooperative trial model with dramatic improvements in outcomes. As an example, survival for advanced Burkitt lymphoma is now\u00a0&gt;95%. Major remaining challenges include survival for relapsed and refractory disease and long\u2010term morbidity in NHL survivors. Langerhans cell histiocytosis (LCH) was added to the NHL Committee portfolio in recognition of LCH as a neoplastic disorder and the tremendous unmet need for improved outcomes. The goal of the Children\u2019 Oncology Group NHL Committee is to identify optimal cures for every child and young adult with NHL (and LCH). 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