{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:59:15Z","timestamp":1778857155086,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Three\u2010dimensional conformal RT (3D\u2010RT) techniques are gold standard for post\u2010operative flank radiotherapy (RT) in paediatric renal tumours. Recently, highly conformal RT (HC\u2010RT) techniques have been implemented without comparative clinical data. The main objective of this multicentre study was to compare locoregional control (LRC) in children treated either with HC\u2010RT or 3D\u2010RT techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients treated with post\u2010operative flank RT for renal tumour registered in the national cohort PediaRT between March 2013 and September 2019 were included. Treatment and follow\u2010up data, including toxicities and outcomes, were retrieved from the database. LRC was calculated, and dose reconstruction was performed in case of an event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010nine patients were included. Forty patients were treated with HC\u2010RT and 39 with 3D\u2010RT. Median follow\u2010up was 4.5\u00a0years. Three patients had locoregional failure (LRF; 4%). HC\u2010RT was not associated with a higher risk of LRF. Three\u2010year LRC were 97.4% and 94.7% in the HC\u2010RT and 3D\u2010RT groups, respectively. The proportion of planning target volumes receiving 95% or more of the prescribed dose did not significantly differ between both groups (HC\u2010RT 88%; 3D\u2010RT 69%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.05). HC\u2010RT was better achieving dose constraints, and a significant mean dose reduction was observed in the peritoneal cavity and pancreas associated with lower incidence of acute gastrointestinal toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LRF after post\u2010operative flank RT for renal tumours was rare and did not increase using HC\u2010RT versus 3D\u2010RT techniques. Dose to the pancreas and the peritoneal cavity, as well as acute toxicity, were reduced with HC\u2010RT compared to 3D\u2010RT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30627","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T05:12:12Z","timestamp":1692076332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Post\u2010operative flank irradiation using conformal versus highly conformal radiotherapy techniques for paediatric renal tumours: Results from the French registry PediaRT"],"prefix":"10.1002","volume":"70","author":[{"given":"Gaelle","family":"Le Quellenec","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Institut de Canc\u00e9rologie de l'Ouest  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Bernier\u2010Chastagner","sequence":"additional","affiliation":[{"name":"Department of Radiation 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