{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:05:52Z","timestamp":1773680752764,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nodular lymphocyte\u2010predominant Hodgkin lymphoma (NLPHL), recently known as nodular lymphocyte\u2010predominant B\u2010cell lymphoma (NLPBL), accounts for 5%\u201310% of Hodgkin lymphoma (HL). Different morphologic patterns of NLPBL are identified and categorized as typical patterns (type A and B) and variant histologic patterns (types C, D, E, and F).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and method<\/jats:title><jats:p>We investigated different morphologic patterns, CD30 and IgD expression in pediatric patients with NLPBL diagnosed at the Children's Cancer Hospital Egypt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six (53%) of the patients exhibited a typical histologic pattern, whereas the remaining (47%) exhibited variant histologic pattern. Variant histology is associated with unfavorable clinical characteristics, such as advanced stages, B\u2010symptoms, and extranodal involvements, particularly bone marrow and bone infiltration, with <jats:italic>p<\/jats:italic>\u2010values of .06, .05, and 0.01%, respectively. Additionally, 39% of patients with variant histology experienced disease progression or relapse, compared to only 15.2% of patients with typical patterns (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.009). Types C and D are related to decreased event\u2010free survival (EFS), as shown by a <jats:italic>p<\/jats:italic>\u2010value of .05. The 5\u2010year EFS for patients with variant histology was 94.4% for the rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisone (RCHOP) versus 33.3% for the adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD). IgD expression in lymphocyte\u2010predominant (LP) cells was detected in 44 (50%) patients, while CD30 expression in LP cells was found in 39 (44%) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Variant histology of NLPBL was associated with advanced disease stages and a poor prognosis, while expression of IgD and CD30 in LP cells was not. The poor outcome of variant histology improved with the RCHOP regimen.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30647","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:58:57Z","timestamp":1693231137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Variant histology of pediatric nodular lymphocyte\u2010predominant Hodgkin lymphoma with IgD and CD30 expression"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-6290","authenticated-orcid":false,"given":"Nesreen","family":"Ali","sequence":"first","affiliation":[{"name":"Pediatric Oncology and Hematology Department, National Cancer Institute (NCI) Cairo University and Children Cancer Hospital  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad","family":"Moussa","sequence":"additional","affiliation":[{"name":"Clinical Oncology Department Menoufya University and Children Cancer Hospital Egypt  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman","family":"Khorshed","sequence":"additional","affiliation":[{"name":"Pathology Department, National Cancer Institute (NCI) Cairo University and Children Cancer Hospital Egypt  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed S.","family":"Zaghloul","sequence":"additional","affiliation":[{"name":"Radiation Therapy Department, National Cancer Institute (NCI) Cairo University and Children Cancer Hospital Egypt  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Elnashar","sequence":"additional","affiliation":[{"name":"Clinical Research Department Children Cancer Hospital  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Pediatric Oncology and Hematology Department, National Cancer Institute (NCI), Cairo University, Egypt and Child Health Department Sultan Qaboos University  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015851"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.65.3469"},{"key":"e_1_2_9_4_1","article-title":"Lymphocyte\u2010predominant Hodgkin's disease in children: a case study and review of the literature","volume":"2015","author":"Stier J","year":"2015","journal-title":"Case Rep Oncol 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