{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:36:12Z","timestamp":1780727772416,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2020CF364"],"award-info":[{"award-number":["2020CF364"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010transplant cyclophosphamide (PTCy) has been recommended for prevention of graft\u2010versus\u2010host disease (GvHD) following haploidentical hematopoietic cell transplantation (haplo\u2010HCT) for treatment of malignant blood diseases, but disease relapse remains a problem. Although donor lymphocyte infusion (DLI) is reported to be effective for treating post\u2010transplantation relapse, the efficacy and safety of prophylactic\u2010DLI (pro\u2010DLI) post haplo\u2010HCT, and PTCy in pediatric patients with hematological malignancies is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the outcomes of 54 pediatric patients with high\u2010risk myeloid neoplasms who received a PTCy regimen for GvHD prophylaxis and pro\u2010DLI after haploidentical peripheral blood stem cell transplantation. The high\u2010risk myeloid neoplasms in this cohort included acute myeloid leukemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a046) and myelodysplastic syndromes (<jats:italic>n<\/jats:italic>\u00a0=\u00a08).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up was for 19.7 (range: 3.4\u201346.6) months. The cumulative incidences of grade II\u2013IV and III\u2013IV acute GvHD were 37.0% (95% CI: 22.7%\u201348.7%) and 16.7% (95% CI: 6.1%\u201326.0%), respectively. There were no graft\u2010failure events, and the 2\u2010year rate of moderate\/severe chronic GvHD was 8.1% (95% CI: 0%\u201316.7%). The 2\u2010year non\u2010relapse mortality, relapse, disease\u2010free survival, GvHD\u2010free relapse\u2010free survival, and overall survival rates were 5.1% (95% CI: 0%\u201311.7%), 16.6% (95% CI: 5.3%\u201326.6%), 78.9% (95% CI: 68.0%\u201391.6%), 62.2% (95% CI: 49.4%\u201378.3%), and 87.3% (95% CI: 78.3%\u201397.4%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prophylactic donor lymphocyte infusion in the setting of haploidentical hematopoietic cell transplantation with post\u2010transplant cyclophosphamide appears to be effective and safe in pediatric patients with high\u2010risk myeloid neoplasms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30659","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T17:04:32Z","timestamp":1693933472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prophylactic donor lymphocyte infusion after haploidentical hematopoietic cell transplantation and post\u2010transplant cyclophosphamide for treatment of high\u2010risk myeloid neoplasms in children: A retrospective study"],"prefix":"10.1002","volume":"70","author":[{"given":"Shan\u2010shan","family":"Qi","sequence":"first","affiliation":[{"name":"Laboratory of Pediatric Hematology Wuhan Children's Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology Wuhan Children's Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Hematology Wuhan Children's Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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