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Although behavioral interventions exist for non\u2010SCD pain populations, interventions designed to address pain\u2010related impairment in SCD are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty youth (9\u201017 years) with SCD completed a four\u2010week telemedicine pain intervention (NCT04388241). Participants and caregivers completed baseline and post\u2010intervention PROMIS pain measures and the Treatment Evaluation Inventory\u2010Short Form (TEI\u2010SF). Descriptive analyses assessed feasibility and acceptability. Reliable Change Index analyses assessed for significant post\u2010intervention changes in pain functioning. Paired <jats:italic>t<\/jats:italic> test analyses compared baseline and post\u2010intervention opioid prescription fills.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All participants completed at least one treatment session. Eighteen (90%) youth completed all sessions. Youth (100%) and caregivers (94%) rated the intervention as moderately or highly acceptable on the TEI\u2010SF. Forty\u2010seven percent of caregivers and 44% of youth reported reliably significant improvements in pain interference after the intervention (median T\u2010score differences: 24.8 and 23.5, respectively). Sixty\u2010five percent of caregivers (T\u2010score improvement difference: 19.3) and 31% of youth (T\u2010score improvement difference: 32) reported improvements in pain behaviors. There was no significant difference in opioid prescription fills pre\u2010 and post\u2010intervention (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Balance Program is feasible, highly acceptable, and can be delivered remotely to reduce barriers to care. Approximately half of youth and caregivers reported significant declines in pain interference following the intervention, with substantial improvements in functioning for treatment responders. Behavioral pain interventions are important adjunctive treatments to uniquely address functional impairment associated with acute and chronic pain in SCD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30667","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T04:03:48Z","timestamp":1695182628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Feasibility and preliminary efficacy of the Balance Program to reduce pain\u2010related disability in pediatric sickle cell disease"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3557-8502","authenticated-orcid":false,"given":"Megan E.","family":"Connolly","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and Psychiatry and Behavioral Sciences George Washington University School of Medicine and Health Sciences  Washington District of Columbia USA"},{"name":"Divisions of Hematology and 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