{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:04:45Z","timestamp":1753869885239,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010transplant lymphoproliferative disorders (PTLD) develop as a consequence of immune suppression. Programmed death protein 1 (PD\u20101), a regulator of host immune activation, binds to programmed death\u2010ligand 1 (PD\u2010L1) to suppress the T\u2010cell immune response. PD\u20101\/PD\u2010L1 pathway may play a role in PTLD. The objective was to describe intratumoral expression of PD\u2010L1 and PD\u20101 in pediatric monomorphic PTLD, and assess if density of these cells is associated with progression\u2010free survival (PFS) and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Clinical variables and outcome data were collected on B\u2010cell monomorphic PTLD treated in Toronto, Canada between 2000 and 2017. Diagnostic area from tumor tissue was identified to count CD3\u2010positive or PD\u20101\u2010positive cells and CD3\u2010negative lymphoma B cells or PD\u2010L1\u2010positive cells. CD3<jats:sup>+<\/jats:sup>, PD\u20101<jats:sup>+<\/jats:sup>, and PD\u2010L1<jats:sup>+<\/jats:sup> cell densities were compared between cases of PTLD. OS and PFS were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 25 cases of B\u2010cell monomorphic PTLD; majority Burkitt lymphoma (32%) and diffuse large B\u2010cell lymphoma (56%). All cases had CD3<jats:sup>+<\/jats:sup> cells infiltrating the tumor, and median percentage of CD3<jats:sup>+<\/jats:sup> cells was 14% (interquartile range: 6.2%\u201325%). Twelve cases (48%) had PD\u20101<jats:sup>+<\/jats:sup> cell infiltrating (range: 1%\u201383%) and 13 cases (52%) had no PD\u20101<jats:sup>+<\/jats:sup> cells infiltrating. Sixteen cases (64%) had PD\u2010L1<jats:sup>+<\/jats:sup> cells present; however, there was no PD\u2010L1 expression on any Burkitt lymphoma tissue. When comparing PD\u20101 and PD\u2010L1 expression, there was no difference in OS or PFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intratumoral presence of PD\u20101<jats:sup>+<\/jats:sup> and PD\u2010L1<jats:sup>+<\/jats:sup> cells varied in pediatric patients with monomorphic PTLD; however, no relationship to OS and PFS was identified.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30674","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T13:15:16Z","timestamp":1694870116000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PD\u2010L1 and PD\u20101 expression in pediatric post\u2010transplant Burkitt lymphoma and other monomorphic post\u2010transplant lymphoproliferative disorders"],"prefix":"10.1002","volume":"70","author":[{"given":"Ashley V.","family":"Geerlinks","sequence":"first","affiliation":[{"name":"Pediatric Hematology\/Oncology, Children's Hospital Schulich School of Medicine Western University  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Upton","family":"Allen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics, Hospital for Sick Children University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u2010Yee","family":"Ngan","sequence":"additional","affiliation":[{"name":"Division of Pathology Department of Pediatric Laboratory Medicine Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4541-0823","authenticated-orcid":false,"given":"Angela","family":"Punnett","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,16]]},"reference":[{"volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","year":"2017","author":"Swerdlow SH","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13324"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2012.04206.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1375"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(15)70103\u20108"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201010\u20102660"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201013\u20100855"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16680"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100832"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201011\u20101942"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1480767"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13857"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010021\u201003129\u20103"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2394"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.280342"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022019543"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30724"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/517427"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003851"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002537"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411087"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00766"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.3467"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(13)70551\u20105"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.65.9789"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.1889537"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.7009"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.12.015"}],"container-title":["Pediatric Blood &amp; 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