{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:29:07Z","timestamp":1781620147927,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dinutuximab \u03b2 can be used to treat children with high\u2010risk neuroblastoma (NB). Due to its high price, whether dinutuximab \u03b2 is cost\u2010effective for the treatment of high\u2010risk NB remains uncertain. Therefore, assessing the cost\u2010effectiveness of dinutuximab \u03b2 in children with high\u2010risk NB is of high importance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The health utilities and economic outcomes in children with high\u2010risk NB were projected using a partitioned survival model. The individual patient data (IPD) of add\u2010on treatment with dinutuximab \u03b2 (GD2 group) were derived from the literature, while the IPD of traditional therapy (TT group) were obtained from retrospective data of Shanghai Children's Medical Center. Treatment costs included drugs, adverse event\u2010related expenses, and medical resource use. Utility values were obtained from the literature. Costs and quality\u2010adjusted life\u2010years (QALYs) were measured over a 10\u2010year time horizon. Deterministic sensitivity analyses (DSA) and probabilistic sensitivity analyses (PSA) were also conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the TT group, QALY increased in the GD2 group by 0.72 with an increased cost of $171,269.70, leading to an incremental cost\u2010effectiveness ratio of 236,462.75$\/QALY. DSA showed that the price of dinutuximab \u03b2 was the main factor on the results than other parameters. Compared with the TT group, the GD2 group could not be cost\u2010effective in the PSA at the $37,920\/QALY threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results found that dinutuximab \u03b2 is not a cost\u2010effective treatment option for children with high\u2010risk NB unless its price is significantly reduced.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30680","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T13:13:57Z","timestamp":1694870037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cost\u2010effectiveness analysis of dinutuximab \u03b2 for the treatment of high\u2010risk neuroblastoma in China"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6706-5920","authenticated-orcid":false,"given":"An\u2010Le","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Pharmacy Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7592-4115","authenticated-orcid":false,"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ting","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An\u2010An","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Medicine &amp; 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