{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:33:21Z","timestamp":1785285201148,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5K07CA211956"],"award-info":[{"award-number":["5K07CA211956"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Children with acute leukemia are at increased risk of kidney injury. Using electronic health record data from three centers between 2010 and 2018, this study retrospectively described acute kidney injury (AKI) and chronic kidney disease (CKD) prevalence in children with acute lymphoblastic or myeloid leukemia (ALL, AML) using Common Terminology Criteria for Adverse Events (CTCAE) and Kidney Disease Improving Global Outcomes (KDIGO) definitions. AKI during therapy was 25% (ALL) and 32% (AML) using CTCAE, versus 84% (ALL) and 74% (AML) using KDIGO. CKD prevalence was low and Grade 1\/Stage 2. Further investigation is needed to optimally define kidney injury in acute leukemia.<\/jats:p>","DOI":"10.1002\/pbc.30696","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T07:38:25Z","timestamp":1696059505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN)"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1186-669X","authenticated-orcid":false,"given":"Wendy","family":"Hsiao","sequence":"first","affiliation":[{"name":"Division of Nephrology Children's Hospital Los Angeles  Los Angeles California USA"},{"name":"Division of Nephrology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimei","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Oncology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Biostatistics Epidemiology, and Informatics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Getz","sequence":"additional","affiliation":[{"name":"Division of Oncology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Biostatistics Epidemiology, and Informatics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6157-6893","authenticated-orcid":false,"given":"Lusha","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Health Informatics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Health Informatics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Health Informatics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Lee","sequence":"additional","affiliation":[{"name":"Aflac Cancer &amp; Blood Disorders Center Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Monica","family":"Gramatges","sequence":"additional","affiliation":[{"name":"Cancer and Hematology Center Texas Children's Hospital  Houston Texas USA"},{"name":"Division of Hematology\u2010Oncology Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen R.","family":"Rabin","sequence":"additional","affiliation":[{"name":"Cancer and Hematology Center Texas Children's Hospital  Houston Texas USA"},{"name":"Division of Hematology\u2010Oncology Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Scheurer","sequence":"additional","affiliation":[{"name":"Cancer and Hematology Center Texas Children's Hospital  Houston Texas USA"},{"name":"Division of Hematology\u2010Oncology Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Aplenc","sequence":"additional","affiliation":[{"name":"Division of Oncology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Denburg","sequence":"additional","affiliation":[{"name":"Division of Nephrology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Biostatistics Epidemiology, and Informatics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-5376","authenticated-orcid":false,"given":"Tamara P.","family":"Miller","sequence":"additional","affiliation":[{"name":"Aflac Cancer &amp; 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