{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:14:12Z","timestamp":1790100852831,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with sickle cell disease (SCD) frequently present with acute pain. The abdomen, a common site of acute SCD\u2010related pain, may be present in a variety of gastrointestinal (GI) pathologies. Limited data exist on prevalence and workup of abdominal pain in patients with SCD during acute pain events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Determine prevalence of GI symptoms, GI\u2010specific evaluation and risks of hospitalization in children with SCD presenting to the emergency department (ED) or hospitalized with abdominal pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of children less than 21\u00a0years presenting to the ED or hospitalized with pain in our center over 2\u00a0years. Descriptive statistics were used to report clinical characteristics, frequency of GI symptoms, workup by age (&lt;5 vs. \u22655\u00a0years), and genotype (sickle cell anemia [SCA] vs. non\u2010SCA). Logistic regression models were used to identify risks associated with hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1279 encounters in 378 patients were analyzed; 23% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0291) encounters were associated with abdominal pain. More abdominal pain\u2010associated hospitalizations occurred in older children, SCA, children with lower mean hemoglobin (8.7\u00a0\u00b1\u00a01.9 vs. 9.6\u00a0\u00b1\u00a01.6\u00a0g\/dL, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and higher mean white blood cell (WBC) count (14.9\u00a0\u00b1\u00a06.6 vs. 13.2\u00a0\u00b1\u00a05.3\u00a0\u00d7\u00a010<jats:sup>3<\/jats:sup>\/\u03bcL, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02). We identified that less than 50% of patients presenting to the ED with abdominal pain received a GI\u2010specific evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children with SCD frequently present with abdominal pain and other GI symptoms, with limited GI evaluations performed. GI\u2010specific evaluation may increase diagnosis of GI pathologies, rule out GI pathologies, and contribute to the limited knowledge of the abdomen as a primary site of SCD pain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30699","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T08:39:40Z","timestamp":1696408780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gastrointestinal symptoms, diagnostic evaluations, and abdominal pathology in children with sickle cell disease"],"prefix":"10.1002","volume":"70","author":[{"given":"Chinenye R.","family":"Dike","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Gastroenterology Hepatology and Nutrition University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Fittro","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Oster","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey D.","family":"Morrow","sequence":"additional","affiliation":[{"name":"Department of Cell Developmental and Integrative Biology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-0470","authenticated-orcid":false,"given":"Amanda","family":"Brandow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Pediatric Hematology\/Oncology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Demark\u2010Wahnefried","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Lebensburger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology and Oncology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21807"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2020.102531"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.06.029"},{"issue":"2","key":"e_1_2_10_5_1","first-page":"100","article-title":"Abdominal pain in adult sickle cell disease patients: a nigerian experience","volume":"9","author":"Akingbola TS","year":"2011","journal-title":"Ann Ib Postgrad Med"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2004.11.007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000436436.83015.5e"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22395"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.02.016"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016\u20105085(86)90276\u20103"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096\u20108652(199806)58:2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21575"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.1.e7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2020.09.052"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/20469047.2021.1936393"},{"issue":"7","key":"e_1_2_10_16_1","first-page":"361","article-title":"Helicobacter pylori infection in sickle cell disease","volume":"92","author":"Woods KF","year":"2000","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10344"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010198803000\u201000006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2019.33.7.18971"},{"issue":"2","key":"e_1_2_10_20_1","first-page":"282","article-title":"Renal abscess in a child with sickle cell anemia","volume":"20","author":"Taksande AM","year":"2009","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2004.11.002"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23181"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31824f1516"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/jmu.Jmu_5_17"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.07.050"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.06.071"},{"issue":"3","key":"e_1_2_10_29_1","first-page":"133","article-title":"Prevalence of abdominal ultrasonographic abnormalities in patients with sickle cell disease","volume":"14","author":"Balci A","year":"2008","journal-title":"Diagn Interv Radiol"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26179"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/jmu.Jmu_47_20"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010003\u20100950\u20105"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200006223422502"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2019.33.253.18017"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.1193"},{"issue":"1","key":"e_1_2_10_36_1","first-page":"91","article-title":"Acute pancreatitis in sickle cell crisis","volume":"81","author":"Kumar A","year":"1989","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.14871"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1427"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0004\u201028032008000400010"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.06.028"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2006.09.001"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.30699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:37:34Z","timestamp":1698068254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.30699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,3]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/pbc.30699"],"URL":"https:\/\/doi.org\/10.1002\/pbc.30699","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,3]]},"assertion":[{"value":"2023-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e30699"}}