{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:15:44Z","timestamp":1787163344040,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anemia is extremely common among patients admitted to pediatric intensive care. Alternative treatments to transfusions such as intravenous iron must be considered. There are no published data for a prospective intravenous (IV) iron study focused in the critically ill children. The objective is to examine the safety and efficacy of intravenous iron sucrose infusion to manage anemia in pediatric critical care. A secondary objective is to examine the effect of different dose regimens of iron sucrose (3, 5, and 7\u00a0mg\/kg dose).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>Prospective investigation of intravenous iron sucrose utilization at a tertiary pediatric intensive care unit between October 2017 and November 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all 115 patients received a total of 616 infusions of IV iron. Transferrin saturation index (TSI) was the most common altered iron deficiency biomarker (91.8%). After IV iron treatment, hemoglobin showed a significant increase within a 30\u2010day follow\u2010up (9.2 vs. 11.6\u00a0g\/dL,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). There was also a significant improvement in TSI and serum iron (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Iron deficit replacement was higher in the 7\u00a0mg\/kg dose group (94%) compared to 85.9% in the 5\u00a0mg\/kg regimen and 77.5% in the lower dose group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.008), requiring less doses and a shorter time. Very few mild adverse reactions were reported (1.3% of infusions), with no differences between groups. The most frequent adverse effect was gastrointestinal in three cases. There were no anaphylaxis\u2010like or other serious\/life\u2010threatening adverse effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first study to evaluate intravenous iron therapy in pediatric critical care, providing preliminary evidence of safety and efficacy of IV iron sucrose. The 7\u00a0mg\/kg dose regimen showed higher iron deficit replacement in a shorter time, which could be beneficial in critically ill children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.30734","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T01:13:54Z","timestamp":1698282834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Intravenous iron for critically ill children. Comparison of three dose regimens"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5430-0488","authenticated-orcid":false,"given":"Laura","family":"Butrague\u00f1o\u2010Laiseca","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"},{"name":"Gregorio Mara\u00f1\u00f3n Health Research Institute (IISGM)  Madrid Spain"},{"name":"Pediatrics Department Universidad Complutense de Madrid  Madrid Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Development Origin Network (RICORS) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"de la Mata Navazo","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"},{"name":"Gregorio Mara\u00f1\u00f3n Health Research Institute (IISGM)  Madrid Spain"},{"name":"Pediatrics Department Universidad Complutense de Madrid  Madrid Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Development Origin Network (RICORS) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia Caridad","family":"S\u00e1nchez Galindo","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"},{"name":"Gregorio Mara\u00f1\u00f3n Health Research Institute (IISGM)  Madrid Spain"},{"name":"Pediatrics Department Universidad Complutense de Madrid  Madrid Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Development Origin Network (RICORS) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Santiago Lozano","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"},{"name":"Gregorio Mara\u00f1\u00f3n Health Research Institute (IISGM)  Madrid Spain"},{"name":"Pediatrics Department Universidad Complutense de Madrid  Madrid Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Development Origin Network (RICORS) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200711-1637OC"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-017-0328-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12737"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03430-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0542-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.10.1267"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.12.1499"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001613"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03597-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002885"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2021.12.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4465-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2021.11.010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2018.11.005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.4488"},{"key":"e_1_2_8_18_1","first-page":"2505","volume-title":"Nelson's Textbook of Pediatrics","author":"Kliegman R","year":"2020"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa059"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9394060"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13004"},{"issue":"2","key":"e_1_2_8_22_1","first-page":"115","article-title":"Iron metabolism, inflammation and anemia in critically ill patients. 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