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It has been associated with age less than 5\u00a0years and with comorbid conditions such as cerebrovascular disease, diabetes mellitus, and hypertension. Radiation necrosis is often symptomatic and can be fatal. A pathogenic variant in <jats:italic>RNF213<\/jats:italic> was found in a patient who suffered fatal radiation necrosis. This mutation has been associated with moyamoya disease and may predispose to radiation necrosis.<\/jats:p>","DOI":"10.1002\/pbc.30739","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T14:14:26Z","timestamp":1698243266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fatal brainstem injury following proton radiation in a patient with medulloblastoma and a germline variant in <i>RNF213<\/i>"],"prefix":"10.1002","volume":"71","author":[{"given":"Darren M.","family":"Klawinski","sequence":"first","affiliation":[{"name":"Department of Pediatrics Nemours Children's Health Jacksonville  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine E.","family":"Cottrell","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2688-8680","authenticated-orcid":false,"given":"Kathleen M.","family":"Schieffer","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin A.","family":"Indyk","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kajal","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine R.","family":"Mardis","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana P.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Breneman","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana S.","family":"Osorio","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6532"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.12.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.2224"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2308-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022542"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.08.039"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.11.026"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2019.1659996"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2014.957414"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2014.957415"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930615)71:12<4111::AID-CNCR2820711250>3.0.CO;2-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2017.92"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.02.033"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6359174"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.09.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.04.051"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.07.004"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep13191"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-018-0156-7"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-017-0256-8"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200402000-00003"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-022335"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12575"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.07.005"}],"container-title":["Pediatric Blood &amp; 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