{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:00:09Z","timestamp":1779145209664,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hemophilia A is a disorder resulting in a deficiency of clotting factor VIII that can lead to life\u2010threatening bleeding. Evidence\u2010based guidelines for surgical interventions like cardiac surgery are limited. Anticoagulation is necessary for cardiac bypass, thus risk of bleeding in a patient with hemophilia is increased and requires careful attention to maintain hemostasis. We report the first infant with severe hemophilia A and dilated cardiomyopathy who underwent successful cardiac transplantation, and review the literature on previous cardiac transplant cases in congenital hemophilia. To ensure safe and effective management, a multidisciplinary approach was used to develop the surgical protocol for transplant.<\/jats:p>","DOI":"10.1002\/pbc.30759","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T03:44:58Z","timestamp":1699415098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Balancing anticoagulation and hemostasis in an infant with severe hemophilia A during cardiac transplantation: Review of the literature and development of a surgical protocol"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6212-8910","authenticated-orcid":false,"given":"Katherine","family":"Regling","sequence":"first","affiliation":[{"name":"Division of Hematology Oncology, Department of Pediatrics Children's Hospital of Michigan, Central Michigan University College of Medicine  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics Children's Hospital of Michigan, Central Michigan University College of Medicine  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Hollon","sequence":"additional","affiliation":[{"name":"Detroit Medical Center Children's Hospital of Michigan  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7423-8052","authenticated-orcid":false,"given":"Patricia","family":"Rayner","sequence":"additional","affiliation":[{"name":"Detroit Medical Center Children's Hospital of Michigan  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Stricker","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Children's Hospital of Michigan, Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit","family":"Sarnaik","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Department of Pediatrics Children's Hospital of Michigan, Central Michigan University College of Medicine  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Sassalos","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiovascular Surgery Children's Hospital of Michigan  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamdouh","family":"Al\u2010Ahmadi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiovascular Surgery Children's Hospital of Michigan  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhvi","family":"Rajpurkar","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology, Department of Pediatrics Children's Hospital of Michigan, Central Michigan University College of Medicine  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meera B.","family":"Chitlur","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology, Department of Pediatrics Children's Hospital of Michigan, Central Michigan University College of Medicine  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12672"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201009\u2010457036"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12913"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2021.09.013"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.09.118"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.04.095"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31822f1b63"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102516.2001.00483.x"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"790","article-title":"Heart transplant in a hemophiliac with an acquired factor VIII inhibitor: synthesis of factor VIII:c in pericardial fluid","volume":"20","author":"Bontempo F","year":"1988","journal-title":"Transpl Proc"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010003\u20101748\u20105"}],"container-title":["Pediatric Blood &amp; 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