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This suggests the novel idea that <jats:italic>MLLT10<\/jats:italic> fusions are capable of driving B\u2010cell malignancies. An <jats:italic>IGH<\/jats:italic> deletion usually only seen in adults was also found. These unique genetic findings provide novel insights into B\u2010cell lymphomagenesis. The child remains in remission 7\u00a0year post chemotherapy, which demonstrates that novel complex molecular findings do not always denote high\u2010risk disease.<\/jats:p>","DOI":"10.1002\/pbc.30810","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T12:45:33Z","timestamp":1702730733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Challenging our understanding of B\u2010cell lymphomagenesis and risk: Paediatric high\u2010grade B\u2010cell lymphoma, not otherwise specified with a <i>DDX3X::MLLT10<\/i> fusion and an <i>IGH<\/i> deletion"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8159-6165","authenticated-orcid":false,"given":"Lucy","family":"Hare","sequence":"first","affiliation":[{"name":"Department of Pathology University of Cambridge  Cambridge UK"},{"name":"Department of Paediatric Haematology, Oncology and Palliative Care Addenbrooke's Hospital  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-4121","authenticated-orcid":false,"given":"Jamie","family":"Trotman","sequence":"additional","affiliation":[{"name":"East\u2010Genomics Laboratory Hub (GLH) Genetics Laboratory Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Tarpey","sequence":"additional","affiliation":[{"name":"East\u2010Genomics Laboratory Hub (GLH) Genetics Laboratory Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Hook","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Cambridge  Cambridge UK"},{"name":"Department of Pathology Addenbrooke's Hospital  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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