{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:04:55Z","timestamp":1753869895181,"version":"3.41.2"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:00:00Z","timestamp":1703462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P50 CA126752\u201013","1R03CA272955\u201001","R01CA284531"],"award-info":[{"award-number":["P50 CA126752\u201013","1R03CA272955\u201001","R01CA284531"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010chromosomal birth defects are an important risk factor for several childhood cancers. However, these associations are less clear for Hodgkin lymphoma (HL). Therefore, we sought to more fully elucidate the association between non\u2010chromosomal birth defects and HL risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Information on cases (<jats:italic>n<\/jats:italic>\u00a0=\u00a0517) diagnosed with HL (ages of 0\u201314) at Children's Oncology Group Institutions for the period of 1989\u20132003 was obtained. Control children without a history of cancer (<jats:italic>n<\/jats:italic>\u00a0=\u00a0784) were identified using random digit dialing and individually matched to cases on sex, race\/ethnicity, age, and geographic location. Parents completed comprehensive interviews and answered questions including whether their child had been born with a non\u2010chromosomal birth defect. To test the association between birth defects and HL risk, conditional logistic regression was applied to generate adjusted odds ratios (aORs) and 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children born with any non\u2010chromosomal birth defect were not more likely to be diagnosed with HL at 0\u201314 years of age (aOR: 0.91; 95% CI: 0.69\u20131.21). No associations were detected between major or minor birth defects and HL (aOR: 1.34; 95% CI: 0.67\u20132.67 and aOR: 0.88; 95% CI: 0.57\u20131.34, respectively). Similarly, no association was observed for children born with any birth defect and EBV\u2010positive HL (aOR: 0.57; 95% CI: 0.25\u20131.26).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Previous assessments of HL in children with non\u2010chromosomal birth defects have been limited. Using data from the largest case\u2013control study of HL in those\u00a0&lt;15 years of age, we did not observe strong associations between being born with a birth defect and HL risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30822","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T04:09:06Z","timestamp":1703563746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of non\u2010chromosomal birth defects on the risk of developing childhood Hodgkin lymphoma: A Children's Oncology Group study"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-8381","authenticated-orcid":false,"given":"Erin C.","family":"Peckham\u2010Gregory","sequence":"first","affiliation":[{"name":"Department of Pediatrics Section of Hematology\u2010Oncology Baylor College of Medicine One Baylor Plaza  Houston Texas USA"},{"name":"Department of Pediatrics Texas 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Hematology Centers Texas Children's Hospital Feigin Center  Houston Texas USA"},{"name":"Department of Pediatrics Center for Epidemiology and Population Health Baylor College of Medicine One Baylor Plaza  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Logan G.","family":"Spector","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Clinical Research Department of Pediatrics University of Minnesota  Minneapolis Minnesota USA"},{"name":"Department of Pediatrics University of Minnesota Masonic Cancer Center  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy M.","family":"Linabery","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Neuroscience Institute Children's Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9817-4011","authenticated-orcid":false,"given":"Erik B.","family":"Erhardt","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics University of New Mexico  Albuquerque New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8095-5979","authenticated-orcid":false,"given":"Karina B.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Collective Health Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl E.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Hematology\u2010Oncology Baylor College of Medicine One Baylor Plaza  Houston Texas USA"},{"name":"Department of Pediatrics Texas Children's Cancer and Hematology Centers Texas Children's Hospital Feigin Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael 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